The Protection of Choline Dehydrogenase by Its Substrate.
ABSTRACT Choline dehydrogenase, an enzyme bound to the mitochondrial inner membrane, plays an important role in the mitochondrial respiratory chain. The purified enzyme is different from the membrane bound enzyme in some properties. The inactivation effects of temperature and SDS on choline dehydrogenase were studied. It was found that the substrate choline had significant protective effect. It was suggested that its substrate could induce the conformational changes of choline dehydrogenase.