Moderating Effects of Coping on the Relationship Between Stress and the Development of New Brain Lesions in Multiple Sclerosis

University of California, VAMC, San Francisco, CA 94121, USA.
Psychosomatic Medicine (Impact Factor: 3.47). 09/2002; 64(5):803-9. DOI: 10.1097/01.PSY.0000024238.11538.EC
Source: PubMed


Many patients with multiple sclerosis (MS) report that stress can trigger disease exacerbations. Considerable research has supported a relationship between stress and both clinical exacerbation and the development of new brain lesions. However, these relationships are not always consistent either within patients or across patients, suggesting the presence of moderators. This study examined the hypothesis that coping moderates the subsequent relationship between stress and the development of new brain lesions in MS.
Thirty-six patients (mean age = 44.4; 22 women, 14 men) with relapsing forms of MS were assessed once every 4 weeks for 28-100 weeks. New brain lesions were identified using monthly Gd+ MRI. Stress was measured within 24 hours before MRI using a modified version of the Social Readjustment Rating Scale that assessed Conflict and Disruption in Routine. Coping was measured at baseline using the Coping with Health Injuries and Problems questionnaire, which produces four scales: distraction, instrumental, palliative, and emotional preoccupation. Data were analyzed using mixed effects logistic regression to account for within-subject correlations. Analyses were lagged such that stress assessments predicted new Gd+ MRI brain lesions 8 weeks later.
As reported previously, stress was significantly related to the development of new Gd+ brain lesions 8 weeks later (OR = 1.62, p =.009). Greater use of distraction was found to be a significant moderator of the relationship between stress and new Gd+ lesions (OR = 0.69, p =.037) such that greater use of distraction was associated with a decreased relationship between stress and new Gd+ lesions. Increased instrumental coping was marginally associated with a decreased relationship between stress and new Gd+ lesions (OR = 0.77, p =.081), while increased emotional preoccupation was marginally associated with an increased relationship between stress and new Gd+ lesions (OR = 1.46, p =.088). There was no significant moderating effect for palliative coping (p =.27) and no significant main effects for any coping variables and the subsequent development of new Gd+ brain lesions (p values >.21).
These findings provide modest support for the hypothesis that coping can moderate the relationship between stress and the MS disease activity. Several limitations in this study are discussed. While these findings suggest areas of potentially fruitful research, readers are cautioned that these are preliminary results; inferences regarding the clinical importance of these findings are premature.

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    • "A meta-analysis [33] of the relationship between stressful life events and MS exacerbations found a clinically meaningful effect size. This supports earlier work showing an increased risk of brain lesions 8 weeks after the occurrence of stress, with preoccupation and coping as moderators of this effect [34]. The stress reduction techniques and meditation taught at the retreats may assist participants in coping with high levels of stress and drive the considerable improvements in the mental health composite scores. "
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    ABSTRACT: There is a strong body of evidence that supports the use of non-drug therapies in the management of people with multiple sclerosis (MS). A 5-day residential retreat for people with MS in Victoria, Australia, promotes lifestyle modification within a patient-centred model of care. Analysis of the health-related quality of life (HRQOL) of the retreat participants was undertaken using the MSQOL-54, prior to attendance, 1 and 5 years after the retreat. 274 retreat participants (71%) completed baseline questionnaires. Despite the usually progressive nature of MS, the cohort demonstrated clinically and statistically significant improvements in HRQOL. One year after attending the retreat, median improvements of 11.3% were observed in the overall quality of life domain (p < 0.001); 18.6% in the physical health composite (p < 0.001); and 11.8% in the mental health composite (p < 0.001). In the subset of 165 who had reached the 5-year time-point, there was a 19.5% median improvement in overall quality of life (p < 0.001); 17.8% in the physical health composite (p < 0.001) and 22.8% in the mental health composite (p < 0.001), compared to baseline. Attendance at a retreat promoting lifestyle modification for the integrated management of MS appears to have positive effects on short and medium-term HRQOL. Non-drug therapies should be considered as part of any comprehensive treatment plan for people with MS.
    Neurological Sciences 02/2012; 34(2). DOI:10.1007/s10072-012-0982-4 · 1.45 Impact Factor
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    • "The sample size of this study was, however, too small for a conclusive finding. In addition to increased risk of clinical relapses, stressful events have also been associated with radiological disease activity as evidenced by new Gd+ brain lesions within 8 weeks of the event [6] [7]. "
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    Journal of the neurological sciences 11/2009; 288(1-2):42-4. DOI:10.1016/j.jns.2009.10.012 · 2.47 Impact Factor
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    • "Other evidence of the moderator model mentioned in previous research work included Felton and Revenson (1984), who proposed that coping strategies may have different consequences when used in response to different types of stressors. Moreover, Mohr et al. (2002) found that coping could moderate the relationship between stress and the disease activity of multiple sclerosis. Findings from this study also agree with what McFarlane (1988a) suggested — the fact that the General Health Questionnaire and the IES, two widely used scales in postdisaster studies (McFarlane, 1988a,b, 1989; Marmar et al., 1996, 1999; Chung et al., 2001, 2004; Chang et al., 2003), reflect relatively separate phenomena. "
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    Psychiatry Research 03/2008; 158(2):164-71. DOI:10.1016/j.psychres.2006.07.015 · 2.47 Impact Factor
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