Article

Pharmaceutical availability of betamethasone dipropionate and gentamicin sulfate from cream and ointment.

Department of Clinical Pharmacy, K. Marcinkowski Medical University, Poznań, Poland.
Acta poloniae pharmaceutica (impact factor: 0.66). 59(2):99-103. pp.99-103
Source: PubMed

ABSTRACT Kinetics of drug release from both compared preparations occuring as a cream and ointment, was in vitro studied. A reversed-phase HPLC method was developed for the determination of betamethasone dipropionate in lipophylic bases. Analyses were performed using a PLRP column with a mobile phase of methanol-acetonitrile-water and ultraviolet detection at lambda = 254 nm. The calibration curve was constructed for concentration (.0-50.0 microg/ml. The method is simple, accurate and precise. For the determination of gentamicin sulfate the FPIA method was used.

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Keywords

betamethasone dipropionate
 
drug release
 
FPIA method
 
gentamicin sulfate
 
Kinetics
 
lipophylic bases
 
mobile phase
 
ointment
 
PLRP column
 
precise
 
reversed-phase HPLC method
 
ultraviolet detection
 

Stanisław Dyderski