Article

Functional proteomics to study protection of the ischaemic myocardium.

Department of Physiology, Division of Cardiology, University of California, Los Angeles, CA 90095, USA.
Expert opinion on therapeutic targets (impact factor: 3.72). 11/2002; 6(5):563-70. DOI:10.1517/14728222.6.5.563
Source: PubMed

ABSTRACT Mechanisms to reduce the deleterious effects of myocardial ischaemia are of particular clinical importance and have been the focus of intense research for a number of years. Among novel approaches to studying the ischaemic heart, proteomics, or the analysis of all cellular proteins, presents as a powerful method to deconstruct the mechanisms of disease and protection. Specifically, the field of functional proteomics is an emerging application of proteomics that melds aspects of classical proteomics, biochemistry, molecular biology and physiology into an approach that facilitates an understanding of how proteins and protein interactions engender phenotype. This review highlights different types of proteomic applications and provides a prospectus for functional proteomics as a robust vehicle driving drug discovery and design.

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Keywords

cellular proteins
 
classical proteomics
 
deleterious effects
 
drug discovery
 
emerging application
 
functional proteomics
 
intense research
 
ischaemic heart
 
molecular biology
 
myocardial ischaemia
 
novel approaches
 
particular clinical importance
 
physiology
 
presents
 
protein interactions engender phenotype
 
proteins
 
proteomic applications
 
proteomics
 

Thomas M Vondriska