Genetics of Childhood Disorders: XLIV. Autism, Part 3: Psychopharmacology of Autism

Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Journal of the American Academy of Child & Adolescent Psychiatry (Impact Factor: 7.26). 12/2002; 41(11):1380-3. DOI: 10.1097/00004583-200211000-00021
Source: PubMed
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    • "In addition, many children with autism have associated behavioral symptoms that interfere with daily function and which are frequent presenting complaints for families seeking additional treatment [3] [4] [5]. These symptoms include anxiety, obsessive/compulsive features , aggression, self injurious behaviors, mood swings, hyperactivity and attentional issues, and sleep disturbance [6] [7] [8]. The presenting symptom may be associated causally with other symptoms and identification of the symptom cluster has been postulated as a useful way to make treatment decisions [4] [5]. "
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    ABSTRACT: The validity of the Parental Concerns Questionnaire, a brief screening checklist assessing the presence and severity of 13 developmental and behavioral concerns expressed by parents of children with autism spectrum disorders, was determined in 53 children ages 4 to 10 years with a clinical diagnosis of autism spectrum disorder and 48 age-matched typically developing controls. Parents completed the Parental Concerns Questionnaire, the Child Behavior Checklist, the Child Sleep Habits Questionnaire, and either the Repetitive Behavior Scale or the Compulsive Behavior Checklist. A clinical examiner administered the Peabody Picture Vocabulary Test and the Autism Diagnostic Observation Scale. The Parental Concerns Questionnaire demonstrated high internal consistency in the autism spectrum disorder subgroup. Reliability and stability over time were demonstrated. Analyses showed variability in item responses for each child indicating that parents were not globally answering all items as concerns. Comparison of Parental Concerns Questionnaire item scores to scores for similar multiquestion domains on standardized parent-rated and clinician-administered assessment tools demonstrated external validity with other parent-rated and clinician-rated instruments. The Parental Concerns Questionnaire is a reliable screening instrument to assess parentally reported developmental and behavioral symptoms in children with autism spectrum disorders.
    Pediatric Neurology 09/2007; 37(2):108-16. DOI:10.1016/j.pediatrneurol.2007.04.013 · 1.70 Impact Factor
    • "Studies of fl uoxetine (Prozac) indicate favorable results, although possible side effects include hyperactivity, agitation, decreased appetite, and aggression (Cook, Rowlett, Jaselskis, & Leventhal, 1992). The use of psychostimulants (e.g., Ritalin) has generally resulted in mixed results (McDougle & Posey, 2002). While motor hyperactivity and poor attention may improve in some children with autism, adverse side effects of aggression and irritability have been noted. "
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    ABSTRACT: Autism is a lifelong, severe, developmental disorder that appears initially in infancy and early childhood and impairs the acquisition of some of the most important skills in human life. The disease is characterized by impaired social interactions, verbal and nonverbal communication deficiencies, limited activities and interest, and repetitive behaviors. Often accompanying the disorder are behavioral disturbances, such as self-mutilation and aggression, psychiatric symptoms, and seizures, which necessitate the administration of multiple medications to help the affected individual participate effectively in the educational and rehabilitative process. Dentists caring for these people must be familiar with the manifestations of the disease and its associated features so that they can garner the maximum level of cooperation. They must also be familiar with the medications used to treat the associated features of the disorder because many of these pharmaceuticals cause untoward orofacial and systemic reactions and may precipitate adverse interactions with dental therapeutic agents.
    Journal of the California Dental Association 10/2003; 31(9):681-2, 684, 686-91.
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