Genetics of Childhood Disorders: XLIV. Autism, Part 3: Psychopharmacology of Autism

Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Journal of the American Academy of Child & Adolescent Psychiatry (Impact Factor: 7.26). 12/2002; 41(11):1380-3. DOI: 10.1097/00004583-200211000-00021
Source: PubMed
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    • "In addition, many children with autism have associated behavioral symptoms that interfere with daily function and which are frequent presenting complaints for families seeking additional treatment [3] [4] [5]. These symptoms include anxiety, obsessive/compulsive features , aggression, self injurious behaviors, mood swings, hyperactivity and attentional issues, and sleep disturbance [6] [7] [8]. The presenting symptom may be associated causally with other symptoms and identification of the symptom cluster has been postulated as a useful way to make treatment decisions [4] [5]. "
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    ABSTRACT: The validity of the Parental Concerns Questionnaire, a brief screening checklist assessing the presence and severity of 13 developmental and behavioral concerns expressed by parents of children with autism spectrum disorders, was determined in 53 children ages 4 to 10 years with a clinical diagnosis of autism spectrum disorder and 48 age-matched typically developing controls. Parents completed the Parental Concerns Questionnaire, the Child Behavior Checklist, the Child Sleep Habits Questionnaire, and either the Repetitive Behavior Scale or the Compulsive Behavior Checklist. A clinical examiner administered the Peabody Picture Vocabulary Test and the Autism Diagnostic Observation Scale. The Parental Concerns Questionnaire demonstrated high internal consistency in the autism spectrum disorder subgroup. Reliability and stability over time were demonstrated. Analyses showed variability in item responses for each child indicating that parents were not globally answering all items as concerns. Comparison of Parental Concerns Questionnaire item scores to scores for similar multiquestion domains on standardized parent-rated and clinician-administered assessment tools demonstrated external validity with other parent-rated and clinician-rated instruments. The Parental Concerns Questionnaire is a reliable screening instrument to assess parentally reported developmental and behavioral symptoms in children with autism spectrum disorders.
    Pediatric Neurology 09/2007; 37(2):108-16. DOI:10.1016/j.pediatrneurol.2007.04.013 · 1.70 Impact Factor
    • "Studies of fl uoxetine (Prozac) indicate favorable results, although possible side effects include hyperactivity, agitation, decreased appetite, and aggression (Cook, Rowlett, Jaselskis, & Leventhal, 1992). The use of psychostimulants (e.g., Ritalin) has generally resulted in mixed results (McDougle & Posey, 2002). While motor hyperactivity and poor attention may improve in some children with autism, adverse side effects of aggression and irritability have been noted. "
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    ABSTRACT: Our understanding and treatment of children with autism have changed dramatically since Leo Kanner first formally documented the disorder in 1943. With reference to the historical context, this paper reviews recent research addressing 4 major issues: early detection, intervention, education, and psychopharmacological management of children with autism and related (autistic) spectrum disorders (hereafter, "autism"). We conclude from our review of the evidence that, in the absence of additional, more compelling data, the clinical usefulness of existing screening instruments remains questionable. However, the potential importance of such research is underscored by the clear benefits of early behavioural intervention: despite differences in orientation, outcomes for children with autism can be significantly enhanced with early intensive intervention. Although many questions remain (notably, What are the critical therapeutic components? For whom? For what domains of development? For what level of intensity and duration?), interventions shown to be effective are all carefully planned, engineered, monitored, and designed to target specific skill domains. Including children with autism in regular classes within the public school system poses several challenges, the most pressing of which is the large number of school personnel who need to be trained in evidence-based teaching and behavioural management practices. Finally, psychotropic drugs may help to reduce some symptoms, but they are neither curative nor a substitute for other forms of support and intervention.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie 10/2003; 48(8):506-16. · 2.55 Impact Factor
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