Article
Inverse correlation between memory Gag-specific cytotoxic T lymphocytes and viral replication in human immunodeficiency virus-infected children.
Laboratoire d'Immunopathologie Virale, Unité de Recherche Associée Centre National de la Recherche Scientifique 1930, Institut Pasteur, 75724 Paris Cedex 15, France.
The Journal of Infectious Diseases (impact factor:
6.41).
01/2003;
186(11):1589-96.
DOI:10.1086/345482
pp.1589-96
Source: PubMed
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Citations (0)
- Cited In (6)
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Article: Breast milk cellular HIV-specific interferon γ responses are associated with protection from peripartum HIV transmission.
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ABSTRACT: : Breast milk is a major route of infant HIV infection, yet the majority of breast-fed, HIV-exposed infants escape infection by unknown mechanisms. This study aimed to investigate the role of HIV-specific breast milk cells in preventing infant HIV infection. : A prospective study was designed to measure associations between maternal breast milk HIV-specific interferon-γ (IFN-γ) responses and infant HIV-1 detection at 1 month of age. : In a Kenyan cohort of HIV-infected mothers, blood and breast milk HIV-gag IFN-γ ELISpot responses were measured. Logistic regression was used to measure associations between breast milk IFN-γ responses and infant HIV infection at 1 month of age. : IFN-γ responses were detected in breast milk from 117 of 170 (69%) women. IFN-γ responses were associated with breast milk viral load, levels of macrophage inflammatory protein (MIP) 1α, MIP-1β, regulated upon activation, normal T-cell expressed, and secreted and stromal-cell derived factor 1 and subclinical mastitis. Univariate factors associated with infant HIV infection at 1 month postpartum included both detection and breadth of breast milk IFN-γ response (P = 0.08, P = 0.04, respectively), breast milk MIP-1β detection (P = 0.05), and plasma (P = 0.004) and breast milk (P = 0.004) viral load. In multivariate analyses adjusting for breast milk viral load and MIP-1β, breast milk IFN-γ responses were associated with an approximately 70% reduction in infant HIV infection [adjusted odds ratio (aOR) 0.29, 95% confidence interval (CI) 0.092-0.91], and each additional peptide pool targeted was associated with an approximately 35% reduction in infant HIV (aOR 0.65, 95% CI 0.44-0.97). : These data show breast milk HIV-gag-specific IFN-γ cellular immune responses are prevalent and may contribute to protection from early HIV transmission. More broadly, these data suggest breast milk cellular responses are potentially influential in decreasing mother-to-child transmission of viruses.AIDS (London, England) 08/2012; 26(16):2007-16. · 4.91 Impact Factor -
Article: HIV-1 group M conserved elements vaccine.
PLoS Pathogens 12/2007; 3(11):e157. · 9.13 Impact Factor -
Dataset: Lohman-Payne.AIDS.12
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Keywords
age 5 years
beneficial role
children
CTLs
cytotoxic T lymphocytes
first year
Gag
Gag-
Gag-specific CTLs
HIV)-infected children
HIV-specific CTLs
human immunodeficiency virus
immunodeficiency syndrome
Memory HIV-specific CTLs
Nef-
Pol proteins
Pol-specific CTLs
virus load
