Coagulopathy, hypothermia and acidosis in trauma patients: the rationale for damage control surgery.
ABSTRACT Severe trauma to the torso or extremities often results in significant hemorrhage, which contributes to morbidity and mortality. The pathophysiological mechanisms contributing to this traumatic blood loss are complex. We review its major components: coagulopathy, acidosis and hypothermia, which have led to the concept of damage control surgery.
SourceAvailable from: Hans Christoph PapeJournal of Orthopaedic Trauma 01/2006; 20(3). DOI:10.1097/00005131-200603000-00016 · 1.54 Impact Factor
[Show abstract] [Hide abstract]
ABSTRACT: Uncontrolled hemorrhage is responsible for over 50% of all trauma-related deaths within the first 48 hours after admission. Clinical observations together with recent research resulted in an appreciation of the central role of coagulopathy in acute trauma care. A synopsis is presented of different retrospective analyses based upon datasets from severe multiply injured patients derived from the TR-DGU database (Trauma Registry of the Deutsche Gesellschaft fur Unfallchirurgie (DGU)/ German Society of Trauma Surgery) with respect to frequency, risk stratification and therapeutic options of acute traumatic coagulopathy (ATC).