Article

The TNFd4 allele is correlated to moderate-to-severe acute graft-versus-host disease after allogeneic stem cell transplantation.

Department of Clinical Immunology, and Centre for Allogeneic Stem Cell Transplantation, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden.
British Journal of Haematology (impact factor: 4.94). 12/2002; 119(4):1133-6. pp.1133-6
Source: PubMed

ABSTRACT Certain cytokine gene polymorphisms may be associated with severe acute graft-versus-host disease (GVHD) after allogeneic stem cell transplantation. The present study analysed 196 patients and their donors for TNF-308, TNFd, IL-10-1064 and IL-10-1082 gene polymorphisms. Serum analysis of tumour necrosis factor-alpha (TNF-alpha) and interleukin 10 (IL-10) levels during conditioning therapy was also performed. Among patients with sibling donors, the TNFd allele 4 was significantly correlated with acute GVHD grades II-IV (P < 0.01). Acute GVHD grades II-IV were more common among patients homozygous for the IL-10-1064 allele 13 (P = 0.02). Patients homozygous for the TNF-308 allele (AA) correlated with higher TNF-alpha serum levels during conditioning (P = 0.02).

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Keywords

AA
 
allogeneic
 
cell transplantation
 
Certain cytokine gene polymorphisms
 
conditioning therapy
 
higher TNF-alpha serum levels
 
IL-10-1082 gene polymorphisms
 
patients homozygous
 
present study analysed 196 patients
 
Serum analysis
 
severe acute graft-versus-host disease
 
TNF-alpha
 
TNFd
 
TNFd allele 4