Article

Vulvar carcinoma presenting during pregnancy, associated with recurrent bone marrow hypoplasia: a case report and literature review.

Birmingham Women's Health Care NHS Trust, Department of Obstetrics and Gynaecology, University of Birmingham, Birmingham, United Kingdom.
Gynecologic Oncology (impact factor: 3.89). 12/2002; 87(2):207-9. DOI:10.1006/gyno.2002.6802 pp.207-9
Source: PubMed

ABSTRACT Carcinoma of the vulva has predominantly been a disease of the elderly. Although occasionally it occurs in women under the age of 40 years, carcinoma of the vulva has been rarely diagnosed in pregnancy. Bone marrow hypoplasia can occur as a transient, pregnancy-related event; however, the recurrence of this pathology in future pregnancies is quite rare in the literature.
A 29-year-old woman in her second pregnancy that was complicated by bone marrow hypoplasia had developed a squamous vulvar carcinoma. Each of these two conditions are quite rare in pregnancy, they may have occurred by chance, but there is a hypothetical possibility that bone marrow hypoplasia is an autoimmune disorder, with vulvar carcinoma occurring as a further complication in this immunoimpaired individual.
This case also emphasizes the need to consider malignancy as a differential diagnosis in vulvar ulcers occurring in young women.

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Keywords

29-year-old woman
 
autoimmune disorder
 
bone marrow hypoplasia
 
Carcinoma
 
differential diagnosis
 
future pregnancies
 
hypothetical possibility
 
immunoimpaired individual
 
pathology
 
pregnancy-related event
 
recurrence
 
squamous vulvar carcinoma
 
transient
 
two conditions
 
vulva
 
vulvar carcinoma
 
vulvar ulcers