Article

Long-term prognostic significance of isolated minor electrocardiographic T-wave abnormalities in middle-aged men free of clinical cardiovascular disease (The Multiple Risk Factor Intervention Trial [MRFIT])

Wake Forest University, Winston-Salem, North Carolina, United States
The American Journal of Cardiology (Impact Factor: 3.43). 01/2003; 90(12):1391-5. DOI: 10.1016/S0002-9149(02)02881-3
Source: PubMed

ABSTRACT The presence or new onset of isolated minor T-wave abnormalities (Minnesota Code 5.3 or 5.4) associated with a greater spatial T-axis deviation was shown to be independently predictive of long-term (18.5 years) cardiovascular disease and coronary heart disease mortality. This was tested in a cohort of >11,000 middle-aged men who were free of clinical coronary heart disease in the Multiple Risk Factor Interventional Trial.

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    • "The spatial QRS-T angle and spatial T amplitude do not differentiate between recent (5-10 days) and old (>6 months) MI, but distinguish them from healthy controls (Dilaveris et al. 2001). Minor T-wave abnormalities (Minnesota Code 5.3 or 5.4) have independent long-term (6 years and 18.5 years) prognostic value for CHD and cardiovascular mortality in a cohort of men at high risk but free of CHD at entry (Prineas et al. 2002). Spatial T-axis deviation has independent prognostic value, in a cohort of elderly (•65 years) men and women free of CHD at entry, with regard to CHD death (adjusted hazard ratio 2.0), incident CHD (adjusted hazard ratio 1.6), and all-cause mortality (adjusted hazard ratio 1.5). "
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