Article

Long-term prognostic significance of isolated minor electrocardiographic T-wave abnormalities in middle-aged men free of clinical cardiovascular disease (The Multiple Risk Factor Intervention Trial [MRFIT])

Wake Forest University, Winston-Salem, North Carolina, United States
The American Journal of Cardiology (Impact Factor: 3.43). 01/2003; 90(12):1391-5. DOI: 10.1016/S0002-9149(02)02881-3
Source: PubMed

ABSTRACT The presence or new onset of isolated minor T-wave abnormalities (Minnesota Code 5.3 or 5.4) associated with a greater spatial T-axis deviation was shown to be independently predictive of long-term (18.5 years) cardiovascular disease and coronary heart disease mortality. This was tested in a cohort of >11,000 middle-aged men who were free of clinical coronary heart disease in the Multiple Risk Factor Interventional Trial.

0 Bookmarks
 · 
65 Views
  • [Show abstract] [Hide abstract]
    ABSTRACT: The association of electrocardiographic (ECG) abnormalities with cardiovascular disease and risk factors has been extensively studied in whites and African-Americans. Comparable data have not been reported in Hispanics/Latinos. The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) is a multicenter, community-based, prospective cohort study of men and women of diverse backgrounds aged 18 to 74 years who self-identified as Hispanic/Latinos. Participants (n = 16,415) enrolled from March 2008 to June 2011. We describe the prevalence of minor and major ECG abnormalities and examined their cross-sectional associations with cardiovascular disease and risk factors. The Minnesota code criteria were used to define minor and major ECG abnormalities. Previous cardiovascular disease and risk factors were based on data obtained at baseline examination. Significant differences in prevalent ECG findings were found between men and women. Major ECG abnormalities were present in 9.2% (95% confidence interval 8.3 to 10.1) of men and 6.6% (95% confidence interval 5.8 to 7.3) of women (p <0.0001). The odds of having major ECG abnormalities significantly increased with age, presence of ≥3 cardiovascular risk factors, and prevalent cardiovascular disease, in both men and women. Significant differences in major ECG abnormalities were found among the varying groups; Puerto Ricans and Dominicans had more major abnormalities compared with Mexican men and women. In conclusion, in a large cohort of Hispanic/Latino men and women, prevalence of major abnormalities was low, yet strong associations of major ECG abnormalities with cardiovascular disease and risk factors were observed in both men and women.
    The American journal of cardiology 09/2013; DOI:10.1016/j.amjcard.2013.08.004 · 3.58 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: The aim of this study was to investigate the prognostic utility of isolated T-wave inversion (TWI), QRS duration, and QRS/T angle on electrocardiogram at rest as predictors for sudden cardiac death (SCD) and death from all causes. The assessment of electrocardiographic findings was based on a population-based cohort of 1,951 men (age 42 to 61 years) with a follow-up period of 20 years. Isolated TWI in the absence of ST depression, bundle branch block or major arrhythmias, prolonged QRS duration from 110 to 119 ms, and a wide QRS/T angle of >67° were identified from the 12-lead electrocardiograms. SCD was observed in 171 men (8.3%) during the follow-up. As a single electrocardiographic parameter, TWI (prevalence 2.4%) was associated with an increased risk of SCD (hazard ratio [HR] 3.30, 95% confidence interval [CI] 1.91 to 5.71, p <0.001) after adjustment for age and clinical factors. Similarly, prolonged QRS duration and wide QRS/T angle were significantly related to the risk of SCD, with HR 1.50 (95% CI 1.08 to 2.19, p = 0.017) for QRS duration and HR 3.03 (95% CI 2.23 to 4.14, p <0.001) for QRS/T angle. The integrated discrimination improvement was significant when TWI (0.014, p = 0.036) or QRS/T angle (0.015, p = 0.002) was added to the model with age and clinical factors. In conclusion, TWI, QRS duration, and QRS/T angle are significantly associated with the risk of SCD and death from all causes beyond conventional cardiovascular risk predictors in the general population.
    The American journal of cardiology 01/2014; DOI:10.1016/j.amjcard.2013.12.026 · 3.58 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Subjects 11 adults cochlear implant users, age since 18 till 70 years old (mean 43); 6 male and 5 female; diagnosis-postlingual deafness; used CI over 3 years. Method The aim of study was evaluation of an optimal number of spectral speech coding maxima. The speech audiometry in free field for programmed 8, 10 and 12 spectral maxima and subjective evaluation of quality of speech perception in different acoustic environmental were performed. Results Results of the study showed the better speech intelligibility for programmed 8 (approx. 54%) and 10 spectral maxima (27%). Conclusion The number of speech spectral maxima over 10 is not necessary to increasing of speech intelligibility. In the BTE (behind the ear) speech processor the power consumtion were important reduced for 8 spectral maxima. Application of 810 number of maxima is optimal in first session (switch-on) programming of speech processor.
    Otolaryngologia polska. The Polish otolaryngology 01/2008; 62(6):769-772. DOI:10.1016/S0030-6657(08)70356-1