Article

Detection of JC virus infection in progressive multifocal leukoencephalopathy: the first documented case in Thailand.

Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet 11/2002; 85(10):1139-44.
Source: PubMed

ABSTRACT Progressive Multifocal Leukoencephalopathy (PML) is a demyelinating brain disease caused by human polyoma JC virus (JCV). This disease is an important cause of morbidity and mortality in AIDS patients. Definite diagnosis currently requires a brain biopsy. PCR for JCV of CSF, an emerging diagnostic tool, has a high specificity for the diagnosis of PML in patients with characteristics on clinical and neuroradiological findings. The authors report a 36-year-old woman who presented with prolonged fever, progressive weakness, and slow speech for 2 months. Clinical features and MRI findings were compatible with PML. Qualitative PCR for JCV of CSF showed a positive result. This report emphasizes the yield of PCR, the CSF for JCV in a diagnosis of PML, which may reduce the need for a brain biopsy in such cases.

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Keywords

2 months
 
36-year-old woman
 
authors report
 
characteristics
 
Definite diagnosis
 
demyelinating brain disease
 
emerging diagnostic tool
 
human polyoma JC virus
 
JCV
 
morbidity
 
MRI findings
 
neuroradiological findings
 
PCR
 
PML
 
positive result
 
Progressive Multifocal Leukoencephalopathy
 
progressive weakness
 
Qualitative PCR
 
slow speech