Inhibitory effect of corynoline isolated from the aerial parts of Corydalis incisa on the acetylcholinesterase

College of Pharmacy, Woosuk University, Samrye 565-701, Korea.
Archives of Pharmacal Research (Impact Factor: 2.05). 01/2003; 25(6):817-9. DOI: 10.1007/BF02976997
Source: PubMed


In the course of screening Korean natural products for acetylcholinesterase (AChE) inhibitory activity, it was found that a methanolic extract of the aerial parts of Corydalis incisa (Papaveraceae) showed significant inhibitory effects on AChE. Corynoline isolated from this plant inhibited AChE activity in a dose-dependent manner, and the IC50 value of corynoline was 30.6 microM. The AChE inhibitory activity of corynoline was reversible and noncompetitive.

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