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The high-pathogenicity island is absent in human pathogens of Salmonella enterica subspecies I but present in isolates of subspecies III and VI

Institut für Molekulare Infektionsbiologie, University of Würzburg, Roentgenring 11, D-97070 Würzburg, Germany.
Journal of Bacteriology (Impact Factor: 2.69). 03/2003; 185(3):1107-11. DOI: 10.1128/JB.185.3.1107-1111.2003
Source: PubMed

ABSTRACT In this study we tested 74 Salmonella strains of all eight Salmonella groups and were able to demonstrate the presence of two high-pathogenicity island types in strains of Salmonella groups IIIa, IIIb, and VI. Most high-pathogenicity island-positive isolates produced yersiniabactin under iron-limited conditions and were positive for the high-molecular-weight proteins HMWP1 and HMWP2.

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Available from: Sören Schubert, Jan 24, 2014
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    • "As well as the primary molecule S4, several linear glucosylated hydrolysis products, SX (monomeric), S1 and S5 (dimeric) and S2 (trimeric), analogous to those of enterobactin have also been identified. In addition, some Salmonella strains possess a high pathogenicity island that encodes the catecholate siderophore yersiniabactin and its uptake system (Oelschlaeger et al., 2003). Some strains also make the hydroxamate siderophore aerobactin (Colonna et al., 1985; McDougall and Neilands, 1984; Rabsch and Reissbrodt, 1985). "
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    • "The high-pathogenicity island (HPI), first described in Yersinia pestis , Y. pseudotuberculosis and Y. enterocolitica IB biotype, displays characteristics of a typical pathogenicity island as: (i) it is a large chromosomal DNA fragment (35–45 kb); (ii) it carries virulence genes, namely the yersiniabactin siderophore system essential for the expression of the high-virulence phenotype in yersiniae; (iii) it is inserted at the 3 ¢ -end of a tRNA gene ( asn tRNA ); (iv) its G + C content is different to that of the remainder of the chromosome, and (v) it is flanked by repeated sequences (Carniel et al ., 1996; Bearden et al ., 1997; Pelludat et al ., 1998). A unique characteristic of the HPI is its wide distribution in various members of the family Enterobacteriaceae , above all in extraintestinal pathogenic isolates of E. coli (ExPEC) (Schubert et al ., 1998; Karch et al ., 1999; Bach et al ., 2000; Schubert et al ., 2000; Oelschläger et al ., 2003). In ExPEC strains, the HPI has been found to be functional and most closely associated with virulence compared to other 'traditional' virulence factors (Johnson and Stell, 2000). "
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