[Bone and soft tissue sarcomas treated at the Norwegian Radium Hospital 1980-99].

Onkologisk avdeling, Det Norske Radiumhospital 0310 Oslo.
Tidsskrift for Den norske legeforening 10/2002; 122(21):2089-94.
Source: PubMed


The Norwegian Radium Hospital's sarcoma group is a multidisciplinary group with a leading role in the diagnosis and treatment of bone and soft tissue sarcomas in Norway.
From 1980 through 1999, 1,355 patients with soft tissue sarcoma and 458 patients with bone sarcoma were treated. In a retrospective analysis of trends over time, patients were allocated to consecutive five-year periods.
Patient characteristics were relatively stable, but there was an increasing proportion of soft tissue sarcomas being referred without prior surgery. Treatment principles have remained unchanged, with surgery with or without radiotherapy dominating in soft tissue sarcoma and surgery with or without chemotherapy in bone sarcoma. The amputation rate for bone sarcoma has fallen from 78% to 17%, and survival has increased significantly for both soft tissue and bone sarcoma patients.
The results indicate significant improvements in the quality of treatment of soft tissue and bone sarcoma. More resources for treatment and organizational development of a multidisciplinary group may contribute to improved quality of care.

2 Reads
  • Tidsskrift for Den norske legeforening 10/2002; 122(21):2088.
  • Lakartidningen 01/2004; 100(50):4190-3.
  • [Show abstract] [Hide abstract]
    ABSTRACT: Bone and soft tissue tumours are relatively rare; they make up about 1% of all new cancer cases, but around 10% among children and adolescents. This review paper is based on searches in Medline and our own experience. There are a number of subgroups that require considerable experience. At the slightest suspicion of malignancy, no biopsy should be performed locally; the patient should be referred to a hospital with experience with this tumour type. Specific chromosomal aberrations have been described in several benign and malignant tumours; sarcomas may be divided into two subgroups based on cytogenetics, one with near-diploid karyotype and few chromosomal changes, but with specific translocations and one with complex karyotypes and multiple cytogenetic aberrations. Sarcomas should be karyotyped in order to identify chromosomal changes in general, whereas fluorescent in situ hybridisation and PCR are the most common methods for detecting the relevant, specific translocations. Genomic screening techniques, in particular microarray-based, global analyses of gene activities and copy numbers, will lead to smaller sets of informative gene assays that may be used in routine analysis. Gastrointestinal stromal tumour (GIST) is a tumour in the gastrointestinal tract where immunohistochemical analysis of the c-kit receptor and molecular diagnosis of mutations in the corresponding gene is important, as targeted therapy towards mutated versions of this receptor is available.
    Tidsskrift for den Norske laegeforening 01/2006; 125(23):3286-9.
Show more