Article

Cytotoxic naphthoquinones and plumbagic acid glucosides from Plumbago zeylanica.

National Research Institute of Chinese Medicine, Pettou, Taipei 112, Taiwan, ROC.
Phytochemistry (impact factor: 3.35). 03/2003; 62(4):619-22. pp.619-22
Source: PubMed

ABSTRACT Two plumbagic acid glucosides, 3'-O-beta-glucopyranosyl plumbagic acid and 3'-O-beta-glucopyranosyl plumbagic acid methylester along with five naphthoquinones (plumbagin, chitranone, maritinone, elliptinone and isoshinanolone), and five coumarins (seselin, 5-methoxyseselin, suberosin, xanthyletin and xanthoxyletin) were isolated from the roots of Plumbago zeylanica. All coumarins were not previously found in this plant. Cytotoxicity of these compounds to various tumor cells lines was evaluated, and plumbagin significantly suppressed growth of Raji, Calu-1, HeLa, and Wish tumor cell lines.

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Keywords

3'-O-beta-glucopyranosyl plumbagic acid
 
3'-O-beta-glucopyranosyl plumbagic acid methylester
 
5-methoxyseselin
 
Calu-1
 
compounds
 
maritinone
 
plumbagic acid glucosides
 
Plumbago zeylanica
 
tumor cell lines
 
various tumor cells lines
 
xanthoxyletin
 

Lie-Chwen Lin