Article

Linkage of mild malaria to the major histocompatibility complex in families living in Burkina Faso.

Université de la Méditerranée, Marseille, France.
Human Molecular Genetics (impact factor: 7.64). 03/2003; 12(4):375-8. pp.375-8
Source: PubMed

ABSTRACT Tumor necrosis factor alpha (TNF alpha) is thought to be a critical mediator of malaria fever, and mild malaria was previously reported to be linked to the MHC region containing the tumor necrosis factor alpha gene (TNF). Thirty-four families from Burkina Faso were analyzed to test for linkage between polymorphisms within the MHC region and mild malaria using the maximum-likelihood-binomial (MLB) program. Two-point analysis indicated linkage of mild malaria to TNFd (LOD = 3.27; P = 5.44 x 10(-5)). Using multipoint analysis, we also found evidence for linkage of mild malaria to the MHC region, with a peak close to TNF (LOD = 3.86; P = 1.22 x 10(-5)). Our results support genes within the MHC region being involved in mild malaria. In particular, the genetic variation within TNF may influence susceptibility to mild malaria. Nevertheless, TNF-238, TNF-244 and TNF-308 polymorphisms are unlikely to explain linkage of mild malaria to the MHC region, and the causal mutations remain to be identified.

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Keywords

Burkina Faso
 
causal mutations
 
critical mediator
 
genetic variation
 
linkage
 
malaria fever
 
maximum-likelihood-binomial
 
MHC region
 
mild malaria
 
MLB
 
multipoint analysis
 
polymorphisms
 
results support genes
 
TNF alpha
 
TNF-308 polymorphisms
 
TNFd
 
Tumor necrosis factor alpha
 
tumor necrosis factor alpha gene
 
Two-point analysis
 

Laurence Flori