Article

Adenovirus ascending cholangiohepatitis.

Department of Pathology, Children's Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA.
Pediatric and Developmental Pathology (impact factor: 0.99). 6(2):156-9. DOI:10.1007/s10024-002-0063-4 pp.156-9
Source: PubMed

ABSTRACT Three children, two with liver transplants and one with acquired human immunodeficiency virus (HIV) infection, presented with hepatitis accompanied by elevated gamma glutamyl transpeptidase. Biopsies revealed cholangiohepatitis caused by adenovirus infection. There was a progressive loss of interlobular bile ducts in two of the patients. In one patient, infection of the biliary tree was marked by a necrotizing cholangitis, with adenoviral inclusions noted in the biliary epithelium. In each patient, there was evidence of adenovirus gastrointestinal infection. This is the first report of adenoviral infection of the biliary tree in humans. It is hypothesized that adenovirus cholangiohepatitis occurs as a result of ascending infection from the gastrointestinal tract to the biliary tree.

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Keywords

adenoviral inclusions
 
adenovirus cholangiohepatitis
 
adenovirus gastrointestinal infection
 
adenovirus infection
 
biliary epithelium
 
biliary tree
 
children
 
cholangiohepatitis
 
first report
 
gamma glutamyl transpeptidase
 
human immunodeficiency virus
 
liver transplants
 
necrotizing cholangitis
 
patients
 
progressive loss
 

Marie-Anne Bründler