Article

Left hemispheric dipole locations of the neuromagnetic mismatch negativity to frequency, intensity and duration deviants

Department of Psychiatry, Friedrich-Schiller-University, Philosophenweg 3, D-07743, Jena, Germany.
Cognitive Brain Research (Impact Factor: 3.77). 04/2003; 16(1):83-90. DOI: 10.1016/S0926-6410(02)00222-7
Source: PubMed

ABSTRACT The aim of the current study was to differentiate the sources of neuromagnetic mismatch negativity (MMNm) to deviants of different features. For this purpose, the MMNm of twenty-one healthy subjects (seven males) were recorded left-hemispherically. Subjects were stimulated monaurally in an oddball paradigm with standard tones of 1000 Hz and three different kinds of mismatch tones (frequency, duration and intensity deviants). Data analysis revealed mean MMNm dipole locations anterior, inferior and more medial than the N100m dipoles. The mean difference between the N100m and MMNm dipoles was in the range of up to 6 mm in one dimension. The dipole locations of all three kinds of deviants differed significantly from each other. The MMNm dipoles of both frequency and duration deviants were found to be significantly inferior to the corresponding source of intensity deviants, while the MMNm dipoles of duration and frequency deviants significantly differed in anterior-posterior direction. This differentiation between sources emphasizes the importance of feature analysis in MMN(m) generation.

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    • "In contrast, duration representations are more widely distributed and computationally complex as has been suggested by He [90], [91]. Furthermore, studies evaluating MMNm sources [92], dipole modeling [93], PET [94] and fMRI [95] provided converging evidence of differential sensitivity of cortical fields in superior temporal regions with respect to different types of auditory change in healthy controls. "
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    ABSTRACT: The Mismatch Negativity (MMN) is an event-related potential (ERP) sensitive to early auditory deviance detection and has been shown to be reduced in schizophrenia patients. Moreover, MMN amplitude reduction to duration deviant tones was found to be related to functional outcomes particularly, to neuropsychological (working memory and verbal domains) and psychosocial measures. While MMN amplitude is thought to be correlated with deficits of early sensory processing, the functional significance of MMN latency remains unclear so far. The present study focused on the investigation of MMN in relation to neuropsychological function in schizophrenia. Forty schizophrenia patients and 16 healthy controls underwent a passive oddball paradigm (2400 binaural tones; 88% standards [1 kHz, 80 db, 80 ms], 11% frequency deviants [1.2 kHz], 11% duration deviants [40 ms]) and a neuropsychological test-battery. Patients were assessed with regard to clinical symptoms. Compared to healthy controls schizophrenia patients showed diminished MMN amplitude and shorter MMN latency to both deviants as well as an impaired neuropsychological test performance. Severity of positive symptoms was related to decreased MMN amplitude to duration deviants. Furthermore, enhanced verbal memory performance was associated with prolonged MMN latency to frequency deviants in patients. The present study corroborates previous results of a diminished MMN amplitude and its association with positive symptoms in schizophrenia patients. Both, the findings of a shorter latency to duration and frequency deviants and the relationship of the latter with verbal memory in patients, emphasize the relevance of the temporal aspect of early auditory discrimination processing in schizophrenia.
    PLoS ONE 04/2014; 9(4):e84536. DOI:10.1371/journal.pone.0084536 · 3.23 Impact Factor
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    • "In contrast, vMMN studies based on feature (orientation and/or color)-related regularities localized deviant-specific activity to earlier anatomical structures of the cortical visual system (occipital lobe—BA 19—Kimura et al., 2010; middle occipital gyrus—Urakawa et al., 2010a,b; occipital fusiform regions—BA 17, 18, 19/7—Yucel et al., 2007). The activation of different feature-/stimulus-specific cortical structures by different types of deviants parallels results from irregularity detection in the auditory modality (e.g., Alain et al., 1999; Rosburg, 2003; Grimm et al., 2006). Interestingly, in all of the vMMN studies cited above deviant-specific activity based on higher-order irregularities or on feature irregularities was additionally found in prefrontal cortical regions (mainly the inferior frontal/medial frontal cortex). "
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    • "Furthermore, Alho et al. (1996) observed the MMNm response to a change within a sound pattern, in addition to that elicited by a change in one frequency element of a music chord, with supratemporal sources anterior to the N1 source. Moreover, a number of further studies (Alain, Achim, & Woods, 1999; Escera et al., 2002; Frodl-Bauch, Kathman, Moïler, & Hegerl, 1997; Giard et al., 1995; Leva¨nen et al., 1996; Paavilainen et al., 1991; Rosburg, 2003; Sysoeva, Takegata, & Naä¨ta¨nen, 2006; Takegata et al., 2001) also showed that the MMNs (MMNms) and their fMRI equivalents (Molholm et al., 2005) for different auditory features are generated in separate loci of the auditory cortex, which necessarily dissociates at least some of the MMN loci from that of the N1 to the (common) standard. Thus, it appears that, in the deviant-minus-standard difference waves, the early negativity may be enhanced by the releasefrom-refractoriness of the N1 neurons, whereas its later part is fully accounted for by the ''genuine'' MMN. "
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