Article

Kawasaki syndrome: the Iranian experience.

Department of Pediatrics, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.
Eastern Mediterranean health journal = La revue de santé de la Méditerranée orientale = al-Majallah al-ṣiḥḥīyah li-sharq al-mutawassiṭ 7(1-2):16-25. pp.16-25
Source: PubMed

ABSTRACT Experience with 50 cases of Kawasaki syndrome in the Islamic Republic of Iran is presented. The syndrome occurred mostly in winter and spring with a 2.1:1 male:female ratio. In 72% of cases, the disease occurred between 1 and 5 years of age, and 80% had an antecedent viral or bacterial illness. Eight patents (16%) had microbiological evidence of infection and 19 (38%) had clinical evidence. Five patients had clinical and radiological evidence of sinusitis. Leukocytosis, neutrophilia, bandaemia, elevated erythrocyte sedimentation rate, positive C-reactive protein, reversed albumin/globulin ratio and increased antistreptolysin O titre were other indications of infection and inflammation. Male gender, prolonged fever, white blood cell count > 15,000/mm3 and absolute granulocyte count > 10,000/mm3 were significant risk factors for the development of coronary artery disease (10 patients).

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    Article: Association of sterile pyuria and coronary artery aneurysm in Kawasaki syndrome.
    Mohsen Akhavan Sepahi, Reza Miri, Hasan Taher Ahmadi
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    ABSTRACT: Kawasaki disease (KD) is an inflammatory multiorgan disease of unknown etiology. The most dramatic organ involved is the heart. There were a few studies about cardiac involvement and sterile pyuria. This study guides to determine if sterile pyuria is associated with coronary artery aneurysm (CAA) in KD patients and to consider it as a predicting factor for coronary artery involvement. Forty seven patients with KD were studied by echocardiography in admission and one month later. Urine analysis, complete blood count, erythrocyte sedimentation rate and C-reactive protein were measured in admission. Data were analyzed using SPSS-14 software. Patients' age was ranged from 13 month to 7 years old (mean age of 3.43 ± 1.54 years). Thirty patients (63.8%) were male and 17 patients (36.1%) were female. Cardiac involvement was detected in 32 patients (68%) using echocardiography, of which CAA was reported in 8 cases (17%). Six of CAA (75%) were in association with sterile pyuria, although it was statistically insignificant (P>0.05). Although the majority of patients with CAA had sterile pyuria, this association is not statistically significant, thus it couldn't be considered as a predicting factor for CAA.
    Acta medica Iranica 09/2011; 49(9):606-11.
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Keywords

10 patients
 
5 years
 
absolute granulocyte count
 
albumin/globulin ratio
 
antecedent viral
 
antistreptolysin O titre
 
coronary artery disease
 
erythrocyte sedimentation rate
 
indications
 
inflammation
 
Iran
 
Kawasaki syndrome
 
Leukocytosis
 
neutrophilia
 
positive C-reactive protein
 
radiological evidence
 
white blood cell count
 

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