First live birth after ovarian stimulation using a chimeric long-acting human recombinant follicle-stimulating hormone (FSH) agonist (recFSH-CTP) for in vitro fertilization

Center for Reproductive Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Fertility and Sterility (Impact Factor: 4.59). 04/2003; 79(3):621-3. DOI: 10.1016/S0015-0282(02)04804-5
Source: PubMed


To report the first pregnancy and live birth after ovarian stimulation using a chimeric long-acting human recombinant FSH agonist (recFSH-CTP) for IVF.
Case report.
Tertiary fertility center.
A 32-year-old woman with a 7-year history of primary infertility.
Ovarian stimulation with a single SC injection of 180 microg recFSH-CTP on cycle day 3, followed by daily injections of 150 IU recFSH from cycle day 10 onward, combined with daily GnRH antagonist 0.25 mg SC to prevent a premature LH rise. Final oocyte maturation was induced by 10,000 IU hCG.
First ongoing pregnancy obtained with recFSH-CTP.
Twelve oocytes were retrieved. Ten oocytes were fertilized in vitro by intracytoplasmic sperm injection, and from these 10 oocytes, two embryos were subsequently transferred after 3 days of culture. A pregnancy test 2 weeks after ET was positive, and ultrasound investigation revealed an intact, intrauterine, singleton pregnancy after 12 weeks.
The first pregnancy and live birth was achieved after ovarian stimulation using recFSH-CTP for IVF.

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    • "In 2003, Tae-Ki Yoon and his working group reported a live birth after vitrification in a stimulated IVF-ET program (94). The first IVF birth after ovarian stimulation by a long-acting human recombinant follicle stimulating hormone (rFSH) agonist was reported (95). Dr. Barash and Prof. Dekel demonstrated increased IVF implantation rate following endometrial curettage by Pipelle curette as a simple outpatient procedure (96). "
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    • "A study in healthy female volunteers showed that a single dose of rFSH-CTP induced multiple follicular growth accompanied by a dose-dependent rise in serum inhibin-B (Duijkers et al., 2002). The first live birth after ovarian stimulation using a chimeric long-acting human rFSH agonist (rFSH-CTP) was reported by Beckers et al. (2003). Ovarian stimulation was initiated on day 3 of a spontaneous menstrual cycle with 180 mg rFSH-CTP. "
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