Prognostic value of lymph node staging in gastric cancer.
ABSTRACT The latest TNM classification (5th edition) changed the definition of nodal staging from the anatomical localization to the total number of metastatic lymph nodes. This study was designed to evaluate and compare the prognostic significance of nodal staging between the two widely known staging systems, the TNM classification (TNM) and Japanese Classification for Gastric Cancer (JCGC).
A total of 582 patients who underwent curative gastrectomy with extended lymphadenectomy for gastric cancer were reviewed retrospectively from hospital records. Based on the localization of metastatic nodes according to the JCGC and the total positive node number according to TNM, the patients were divided into subgroups and their prognoses compared.
Lymph node metastasis was found in 189 of the 582 patients (32.5%). Both nodal staging systems were found to be significant prognostic factors by multivariate analysis. A prognostic analysis of the patients by subdivision with the two staging systems indicated that the nodal staging system in TNM was more homogenous than that of the JCGC.
The nodal staging system of the TNM classification is superior to that of the Japanese Classification of Gastric Cancer, because it is simple, reproducible and homogeneous.
SourceAvailable from: mdpi.com[Show abstract] [Hide abstract]
ABSTRACT: Despite a decrease in incidence in recent decades, gastric cancer is still one of the most common causes of cancer death worldwide . In areas without screening for gastric cancer, it is diagnosed late and has a high frequency of nodal involvement . Even in early gastric cancer (EGC), the incidence of lymph node (LN) metastasis exceeds 10%; it was reported to be 14.1% overall and was 4.8 to 23.6% depending on cancer depth . It is important to evaluate LN status preoperatively for proper treatment strategy; however, sufficient results are not being obtained using various modalities. Surgery is the only effective intervention for cure or long-term survival. It is possible to cure local disease without distant metastasis by gastrectomy and LN dissection. However, there is no survival benefit from surgery for systemic disease with distant metastasis such as para-aortic lymph node metastasis . Therefore, whether the disease is local or systemic is an important prognostic indicator for gastric cancer, and the debate continues over the importance of extended lymphadenectomy for gastric cancer. The concept of micro-metastasis has been described as a prognostic factor [4-9], and the biological mechanisms of LN metastasis are currently under study [10-12]. In this article, we review the status of LN metastasis including its molecular mechanisms and evaluate LN dissection for the treatment of gastric cancer.12/2011; 3(2):2141-59. DOI:10.3390/cancers3022141
[Show abstract] [Hide abstract]
ABSTRACT: To evaluate the clinical utility of dual energy spectral CT (DEsCT) in staging and characterizing gastric cancers. 96 patients suspected of gastric cancers underwent dual-phasic scans (arterial phase (AP) and portal venous phase (PP)) with DEsCT mode. Three types of images were reconstructed for analysis: conventional polychromatic images, material-decomposition images, and monochromatic image sets with photon energies from 40 to 140 keV. The polychromatic and monochromatic images were compared in TNM staging. The iodine concentrations in the lesions and lymph nodes were measured on the iodine-based material-decomposition images. These values were further normalized against that in aorta and the normalized iodine concentration (nIC) values were statistically compared. Results were correlated with pathological findings. The overall accuracies for T, N and M staging were (81.2%, 80.0%, and 98.9%) and (73.9%, 75.0%, and 98.9%) determined with the monochromatic images and the conventional kVp images, respectively. The improvement of the accuracy in N-staging using the keV images was statistically significant (p<0.05). The nIC values between the differentiated and undifferentiated carcinoma and between metastatic and non-metastatic lymph nodes were significantly different both in AP (p = 0.02, respectively) and PP (p = 0.01, respectively). Among metastatic lymph nodes, nIC of the signet-ring cell carcinoma were significantly different from the adenocarcinoma (p = 0.02) and mucinous adenocarcinoma (p = 0.01) in PP. The monochromatic images obtained with DEsCT may be used to improve the N-staging accuracy. Quantitative iodine concentration measurements may be helpful for differentiating between differentiated and undifferentiated gastric carcinoma, and between metastatic and non-metastatic lymph nodes.PLoS ONE 02/2013; 8(2):e53651. DOI:10.1371/journal.pone.0053651 · 3.53 Impact Factor
[Show abstract] [Hide abstract]
ABSTRACT: Purpose: For patients with gastric cancer, surgical resection with a lymph node dissection is considered a potentially curative treatment. The prognostic benefit of extended lymph node dissection (D2) is still controversial. Accordingly, our objective in this study is to investigate the feasibility of this type of dissection and the value of intraoperative contrast medium in the demonstration of the lymphatic system and lymph node's draining area and to evaluate the different prognostic factors using univariate and multi-variate analysis and to compare the survival of patients subjected to D2 dissection to a historical group of patients with gastric cancer treated at the NCI Cairo University. Patients and Methods: Thirty-three patients with gastric carcinoma underwent radical gastrectomy with systematic lymph node dissection (D2 dissection) as described by the Japanese Research Society for Gastric Cancer (JRSGC, 1998).