Article

Bazooka is a permissive factor for the invasive behavior of discs large tumor cells in Drosophila ovarian follicular epithelia.

Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch, Robert-Rössle Strasse 10, D-13125 Berlin-Buch, Germany.
Development (impact factor: 6.6). 06/2003; 130(9):1927-35. pp.1927-35
Source: PubMed

ABSTRACT Drosophila Bazooka and atypical protein kinase C are essential for epithelial polarity and adhesion. We show here that wild-type bazooka function is required during cell invasion of epithelial follicle cells mutant for the tumor suppressor discs large. Clonal studies indicate that follicle cell Bazooka acts as a permissive factor during cell invasion, possibly by stabilizing adhesion between the invading somatic cells and their substratum, the germline cells. Genetic epistasis experiments demonstrate that bazooka acts downstream of discs large in tumor cell invasion. In contrast, during the migration of border cells, Bazooka function is dispensable for cell invasion and motility, but rather is required cell-autonomously in mediating cell adhesion within the migrating border cell cluster. Taken together, these studies reveal Bazooka functions distinctly in different types of invasive behaviors of epithelial follicle cells, potentially by regulating adhesion between follicle cells or between follicle cells and their germline substratum.

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Keywords

atypical protein kinase C
 
bazooka acts downstream
 
Bazooka function
 
Bazooka functions distinctly
 
border cells
 
Clonal studies
 
different types
 
Drosophila Bazooka
 
epithelial follicle cells
 
epithelial follicle cells mutant
 
epithelial polarity
 
follicle cell Bazooka acts
 
Genetic epistasis experiments
 
germline substratum
 
invading somatic cells
 
invasive behaviors
 
mediating cell adhesion
 
migrating border cell cluster
 
tumor cell invasion
 
wild-type bazooka function