Evaluation of glaucomatous damage on retinal nerve fiber layer thickness measured by optical coherence tomography.

Department of Organ Therapeutics, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Japan.
American Journal of Ophthalmology (Impact Factor: 3.87). 04/2003; 135(4):513-20. DOI: 10.1016/S0002-9394(02)02003-2
Source: PubMed


To evaluate the relationship between visual field and retinal nerve fiber layer (RNFL) thickness measured by optical coherent tomography (OCT) and to assess the diagnostic ability of OCT to distinguish between early glaucomatous or glaucoma-suspect eyes from normal eyes.
Retrospective, non-randomized, cross-sectional study.
A total of 160 eyes of 120 normal Japanese adults, 23 eyes of 16 patients with ocular hypertension, 38 eyes of 35 glaucoma-suspect patients, and 237 glaucomatous eyes of 140 glaucoma patients were enrolled in the study. The glaucoma group included 89 early glaucomatous eyes. Thickness of the RNFL around the optic disk was determined with three 3.4-mm diameter circle OCT scans. Average and segmental RNFL thickness values were compared among all groups. The correlation between mean deviation and RNFL thickness in glaucomatous eyes was also analyzed. Receiver operating characteristic (ROC) curve area was calculated to discriminate normal eyes from early glaucomatous or glaucoma-suspect eyes.
A significant relationship existed between the mean deviation and RNFL thickness in all parameters excluding the 3-o'clock area. The average RNFL thickness had the strongest correlation in all parameters (r = -0.729, P <.001). Retinal nerve fiber layer thickness at the 7-o'clock inferotemporal segment had the widest areas under the ROC curves in all parameters for early glaucomatous eyes (0.873).
Measurement of RNFL thickness by OCT is useful in detecting early RNFL damage. Furthermore, OCT measurements of RNFL thickness may provide clinically relevant information in monitoring glaucomatous changes.

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    • "Increased thickness along the superior and inferior poles of the optic nerve head gives a typical " double hump " appearance when RNFL thickness is normal [15] [16]. New three dimensional optical coherence tomography (3D-OCT) instruments (Topcon-3D OCT- 1000, OPTOVCUE-RTVue-100, OPTOPOL-SOCT COPERNICUS) are much faster than conventional OCT and have become more sophisticated ophthalmic imaging modalities [13]. "
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    ABSTRACT: Background: Accurate measurement of retinal nerve fiber layer (RNFL) is now possible with the high resolution optical coherence tomography (OCT). Effect of refractive status of the eye on RNFL thickness may be relevant in the diagnosis of glaucoma and other optic nerve diseases. Aim: To assess the RNFL thickness and compare its correlation with refractive status and axial length of the eye. Material and Methods: Three hundred eyes of 150 patients were included in this study, who underwent RNFL analysis using TOPCON 3D OCT 2000. Analysis of variance has been used to find the significance of study parameters between the study groups. Results: The study showed that refractive status/axial length affected the peripapillary RNFL thickness significantly. Conclusion: The study suggests that the diagnostic accuracy of OCT may be improved by considering refractive status and axial length of the eye when RNFL is measured. © 2015,Journal of Clinical and Diagnostic Research. All rights reserved.
    Journal of Clinical and Diagnostic Research 09/2015; 9(9)(9). DOI:10.7860/JCDR/2015/14112.6480 · 0.23 Impact Factor
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    • "When analyzing these correlations according to glaucomatous stages, the correlation between the area of the RNFL defect and MD was significantly stronger in the severe stage than in the mild and moderate stages, whereas the correlation between RNFL thickness and MD did not differ according to glaucomatous stage. Kanamori et al. [12] reported a significant relationship between the MD and RNFL thickness in all parameters excluding the 3-o'clock area. Recently, Leite et al. [13] reported that the relationship was strongest for superotemporal RNFL thickness and inferonasal sensitivity (R2 = 0.314, p < 0.001), using the cirrus spectral domain (SD) OCT. "
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    ABSTRACT: Purpose To evaluate the relationship between the structural damage as assessed by time-domain optical coherence tomography (OCT) and functional changes in glaucoma. Methods In total, 190 patients with normal tension glaucoma or primary open angle glaucoma were included in this study. The thickness of retinal nerve fiber layer (RNFL) around the optic disc and the area of RNFL defect were determined using OCT scans. The relationships between the RNFL thickness or area of the defect and visual field (VF) indices were assessed using the Lowess function, regression analysis and partial Spearman correlation. The differences between these associations depending on the stage of VF damage were further analyzed. Age, optic disc size, refraction, central corneal thickness and the presence of systemic disease were corrected for in order to exclude confounding factors. Results A logarithmic scale of RNFL thickness showed a negative linear relationship with VF indices. The area of the RNFL defect showed a weak correlation with the pattern of standard deviation, whereas the remnant RNFL thickness was moderately correlated with the pattern of standard deviation (partial Spearman correlation coefficient, 0.39, -0.47, respectively; p < 0.0001). Many outliers were detected in the Lowess-plotted graphs. Multiplication of the area and the inverted RNFL thickness showed a moderately correlated logarithmic relationship with the VF indices (partial Spearman correlation coefficient, 0.46; 95% confidence interval, 0.34 to 0.57; p < 0.0001). In the severe stage of VF damage, correlation between the area of the RNFL defect and mean deviation was significantly greater than in other stages (partial Spearman correlation coefficient, -0.66; p = 0.02). Conclusions The thickness of the RNFL had a negative logarithmic correlation with the VF indices and was more relevant to the VF indices than the area of the RNFL defect, as measured by OCT.
    Korean Journal of Ophthalmology 08/2014; 28(4):323-9. DOI:10.3341/kjo.2014.28.4.323
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    • "In another study by Kanamori et al,16 OCT scans were performed using the OCT-2000 system. They reported average RNFL thicknesses higher than Cirrus measurements in the current study (mean thickness of 107.4±13.9 "
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    ABSTRACT: Purpose To determine the agreement between Spectralis and Cirrus spectral domain optical coherence tomography (SD-OCT) measurements of peripapillary retinal nerve fiber layer (RNFL) thickness. Methods Suspected or confirmed cases of glaucoma who met the inclusion criteria underwent peripapillary RNFL thickness measurement using both the Spectralis and Cirrus on the same day within a few minutes. Results Measurements were performed on 103 eyes of 103 patients with mean age of 50.4±17.7 years. Mean RNFL thickness was 89.22±15.87 versus 84.54±13.68 µm using Spectralis and Cirrus, respectively. The difference between measurements and the average of paired measurements with the two devices showed a significant linear relationship. Bland-Altman plots demonstrated that Spectralis thickness values were systematically larger than that of Cirrus. Conclusion Spectralis OCT generates higher peripapillary RNFL thickness readings as compared to Cirrus OCT; this should be kept in mind when values obtained with different instruments are compared during follow-up.
    Journal of Ophthalmic & Vision Research 01/2014; 9(1):31-7.
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