Article

Neurofilaments and neurological disease

Departments of Neuroscience and Neurology, Institute of Psychiatry, King's College London, London SE5 8AF, UK.
BioEssays (Impact Factor: 4.84). 04/2003; 25(4):346-55. DOI: 10.1002/bies.10251
Source: PubMed

ABSTRACT Neurofilaments are one of the major components of the neuronal cytoskeleton and are responsible for maintaining the calibre of axons. They are modified by post-translational changes that are regulated in complex fashions including by the interaction with neighbouring glial cells. Neurofilament accumulations are seen in several neurological diseases and neurofilament mutations have now been associated with Charcot-Marie-Tooth disease, Parkinson's disease and amyotrophic lateral sclerosis. In this review, we discuss the structure, normal function and molecular pathology of neurofilaments.

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