The relationship of thyroid cancer with radiation exposure from nuclear weapon testing in the Marshall Islands.
ABSTRACT The US nuclear weapons testing program in the Pacific conducted between 1946 and 1958 resulted in radiation exposure in the Marshall Islands. The potentially widespread radiation exposure from radio-iodines of fallout has raised concerns about the risk of thyroid cancer in the Marshallese population. The most serious exposures and its health hazards resulted from the hydrogen-thermonuclear bomb test, the Castle BRAVO, on March 1, 1954. Between 1993 and 1997, we screened 3,709 Marshallese for thyroid disease who were born before the BRAVO test. It was 60% of the entire population at risk and who were still alive at the time of our examinations. We diagnosed 30 thyroid cancers and found 27 other study participants who had been operated for thyroid cancer before our screening in this group. Fifty-seven Marshallese born before 1954 (1.5%) had thyroid cancer or had been operated for thyroid cancer. Nearly all (92%) of these cancers were papillary carcinoma. We derived estimates of individual thyroid dose proxy from the BRAVO test in 1954 on the basis of published age-specific doses estimated on Utirik atoll and 137Cs deposition levels on the atolls where the participants came from. There was suggestive evidence that the prevalence of thyroid cancer increased with category of estimated dose to the thyroid.
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ABSTRACT: Background. Thyroid cancer is a common cancer in adolescents and young adults ranking 4th in frequency. Thyroid cancer has captured the interest of epidemiologists because of its strong association to environmental factors. The goal of this study is to identify thyroid cancer clusters in Florida for the period 2000–2008. This will guide further discovery of potential risk factors within areas of the cluster compared to areas not in cluster. Methods. Thyroid cancer cases for ages 15–39 were obtained from the Florida Cancer Data System. Next, using the purely spatial Poisson analysis function in SaTScan, the geographic distribution of thyroid cancer cases by county was assessed for clusters. The reference population was obtained from the Census Bureau 2010, which enabled controlling for population age, sex, and race. Results. Two statistically significant clusters of thyroid cancer clusters were found in Florida: one in southern Florida (SF) (relative risk of 1.26; P value of <0.001) and the other in northwestern Florida (NWF) (relative risk of 1.71; P value of 0.012). These clusters persisted after controlling for demographics including sex, age, race. Conclusion. In summary, we found evidence of thyroid cancer clustering in South Florida and North West Florida for adolescents and young adult.
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ABSTRACT: The beginning of the atomic age marked the outset of nuclear weapons testing, which is responsible for the radioactive contamination of a large number of sites worldwide. The paper aims to analyze nuclear weapons tests conducted in the second half of the twentieth century, highlighting the impact of radioactive pollution on the atmospheric, aquatic, and underground environments. Special attention was given to the concentration of main radioactive isotopes which were released, such as (14)C, (137)Cs, and (90)Sr, generally stored in the atmosphere and marine environment. In addition, an attempt was made to trace the spatial delimitation of the most heavily contaminated sites worldwide, and to note the human exposure which has caused a significantly increased incidence of thyroidal cancer locally and regionally. The United States is one of the important examples of assessing the correlation between the increase in the thyroid cancer incidence rate and the continental-scale radioactive contamination with (131)I, a radioactive isotope which was released in large amounts during the nuclear tests carried out in the main test site, Nevada.AMBIO A Journal of the Human Environment 02/2014; 43(6). DOI:10.1007/s13280-014-0491-1 · 2.97 Impact Factor
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ABSTRACT: Dado el interés actual por los efectos de una detonación nuclear (DN) sobre la población, se aplicaron ecuaciones obtenidas de DN reales para estimar dichos efectos en la ciudad de Valencia, Venezuela. Se simuló por computadora el estallido de un dispositivo de fisión de 15Kt, hipocentro (HC) en el punto medio de la principal avenida, y se consideró el censo poblacional 2002. Cuatro escenarios fueron analizados: A) día nublado, viento 0,1km·h-1, detonación terrestre; B) igual que A pero detonación aérea; C) día soleado, viento 10km·h-1, detonación terrestre; y D) igual a C pero detonación aérea. Resultaron 10069 personas carbonizadas (>10cal·cm-2, <660m del HC), 9737 quemados de 3º (5-10cal·cm-2, 660-930m) y 74855 quemados de 2º (1-5cal·cm-2, 930-2090m) en A; 23847 personas carbonizadas (<1010m), 22125 quemados de 3º (1010-1420m) y 118841 quemados de 2º (1420-3200m) en B; 32658 personas carbonizadas (<1210m), 32791 quemados de 3º (1210-1720m) y 121226 quemados de 2º (1720-3860m) en C; y carbonización de 76674 personas (<1860m), 56837 quemados de 3º (1860-2630m) y 266100 quemados de 2º (2630-5900m) en D. En los 4 escenarios perecerán aproximadamente 68165 personas a <1740m debido a presiones entre 1,39 y 0,135kg·cm-2. Un total de 7419 personas recibirán dosis equivalentes >6Sv; 36632 recibirán de 1 a 6Sv. Las DN terrestres (A y C) generaron el mayor "fallout": 0,05Sv a las 14,6h. y 0,1Sv a los 30min, respectivamente. La radiación acumulada luego de 104 días fue 0,351Sv. Los heridos superarán exponencialmente los centros asistenciales.Interciencia 09/2004; 29(9):485-489. · 0.25 Impact Factor