Fusiform gyrus volume reduction and facial recognition in chronic schizophrenia.

Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston VA Healthcare System, Brockton, MA 02301, USA.
Archives of General Psychiatry (Impact Factor: 13.75). 05/2003; 60(4):349-55. DOI: 10.1001/archpsyc.60.4.349
Source: PubMed

ABSTRACT The fusiform gyrus (FG), or occipitotemporal gyrus, is thought to subserve the processing and encoding of faces. Of note, several studies have reported that patients with schizophrenia show deficits in facial processing. It is thus hypothesized that the FG might be one brain region underlying abnormal facial recognition in schizophrenia. The objectives of this study were to determine whether there are abnormalities in gray matter volumes for the anterior and the posterior FG in patients with chronic schizophrenia and to investigate relationships between FG subregions and immediate and delayed memory for faces.
Patients were recruited from the Boston VA Healthcare System, Brockton Division, and control subjects were recruited through newspaper advertisement. Study participants included 21 male patients diagnosed as having chronic schizophrenia and 28 male controls. Participants underwent high-spatial-resolution magnetic resonance imaging, and facial recognition memory was evaluated. Main outcome measures included anterior and posterior FG gray matter volumes based on high-spatial-resolution magnetic resonance imaging, a detailed and reliable manual delineation using 3-dimensional information, and correlation coefficients between FG subregions and raw scores on immediate and delayed facial memory derived from the Wechsler Memory Scale III.
Patients with chronic schizophrenia had overall smaller FG gray matter volumes (10%) than normal controls. Additionally, patients with schizophrenia performed more poorly than normal controls in both immediate and delayed facial memory tests. Moreover, the degree of poor performance on delayed memory for faces was significantly correlated with the degree of bilateral anterior FG reduction in patients with schizophrenia.
These results suggest that neuroanatomic FG abnormalities underlie at least some of the deficits associated with facial recognition in schizophrenia.

  • [Show abstract] [Hide abstract]
    ABSTRACT: Delusional disorder (DD) is a rare and understudied psychiatric disorder. There is limited number of studies concerning cognitive characteristics in DD. Using an established working memory paradigm with variable levels of memory load, we investigated alterations in functional magnetic resonance imaging (fMRI) of brain regions in patients with DD.
    Journal of Psychiatric Research 05/2014; · 4.09 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Offspring of individuals with psychoses sometimes display an abnormal development of cognition, language, motor performance, social adaptation, and emotional functions. The aim of this study was to investigate the ability of children of mothers with schizophrenia (n = 28) and bipolar disorder (n = 23) to understand mental states of others using the Eyes Test (folk psychology or "theory of mind") and physical causal interactions of inanimate objects (folk physics). Compared with healthy controls (n = 29), the children of mothers with schizophrenia displayed significantly impaired performances on the Eyes Test but not on the folk physics test when corrected for IQ. The children of mothers with bipolar disorder did not differ from the controls. The folk physics test showed a significant covariance with IQ, whereas the Eyes Test did not exhibit such covariance. These results suggest that the attribution of mental states, but not the interpretation of causal interaction of objects, is impaired in offspring of individuals with schizophrenia, which may contribute to social dysfunctions.
    PeerJ. 01/2014; 2:e330.
  • [Show abstract] [Hide abstract]
    ABSTRACT: Ethylene concentration time-histories were measured behind reflected shock waves in ethylene/argon and n-heptane/argon mixtures using 10.5μm CO2 laser absorption. Reflected shock conditions covered temperatures between 1350 and 1950K, pressures between 1.3 and 3.3atm, and fuel concentrations of 1% ethylene and 300ppm n-heptane in argon. The ethylene absorption cross-section at this wavelength was determined over similar pressures and temperatures using both absorption measurements in a heated-cell FTIR and laser absorption/shock tube measurements. Measured ethylene concentration time-histories during ethylene pyrolysis were compared to constant volume simulations using the Marinov et al. (1998) mechanism. A sensitivity of the measured profiles to the rate constant of the primary ethylene decomposition reaction, C2H4→C2H2+H2 was demonstrated, allowing a determination of the rate constant for this reaction using the ethylene time-histories. Ethylene concentrations, measured during n-heptane pyrolysis, were also compared to simulations using the Sirjean et al. (2009)/JetSurF1.0 mechanism. Incorporation of the new reaction rate constant k1 provided better agreement between the measured ethylene concentration profiles and the simulations for both ethylene and n-heptane pyrolysis.
    Proceedings of the Combustion Institute 01/2011; 33(1):333-340. · 3.83 Impact Factor

Full-text (2 Sources)

Available from
May 31, 2014