Systemic 5-fluorouracil producing an inflammatory response in porokeratosis.
ABSTRACT Topical 5-fluorouracil has been used as an effective treatment for porokeratosis. Upon its treatment, an inflammatory effect occurs with the topical 5-fluorouracil. We report a case of a patient with disseminated superficial actinic porokeratosis displaying a comparable inflammatory process following therapy with systemic 5-fluorouracil used to manage a metastatic breast cancer.
- SourceAvailable from: MH Rahman
- Egyptian Dermatology Online Journal Vol. 7 No 2:7, December 2011. 12/2011;
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ABSTRACT: Porokeratosis is a disorder of keratinization, characterized clinically by a peripheral keratotic ridge and histologically by the cornoid lamella. We describe a patient with follicular porokeratosis with a distinctive clinical presentation. We believe that follicular porokeratosis is a unique histopathologic variant of porokeratosis, with cornoid lamellae centered in follicular infundibula. Further, this is the only report of follicular porokeratosis involving the face exclusively.The American Journal of dermatopathology 10/2010; 32(7):720-2. · 1.30 Impact Factor