Borrelia-associated primary cutaneous MALT lymphoma in a nonendemic region.
Article: MALT lymphoma of the foreskin.[Show abstract] [Hide abstract]
ABSTRACT: Here we present the first described case of MALT lymphoma involving the foreskin. The patient presented with a lump proximal to the glans penis. It was treated with radical excision and histology revealed positive margins. No further therapy was given as this may have resulted in significant morbidity. The patient remains relapse free more than 2 years later. MALT lymphomas are the third most common non-Hodgkin lymphoma accounting for 8% of cases. They have been described at almost all extranodal sites but this case is the first involving the foreskin.Leukemia and Lymphoma 09/2004; 45(8):1699-701. DOI:10.1080/10428190410001683813 · 2.61 Impact Factor
- Leukemia and Lymphoma 09/2004; 45(8):1721-3. DOI:10.1080/10428190410001683723 · 2.61 Impact Factor
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ABSTRACT: Aim shistological and clinical relationship study of 44 cases of primary cutaneous B cell lymphoma, classified according to WHO classification. Materials and methods histological, immunological and molecular analysis was correlated with clinical data. Results 33 cases (75%) were marginal zone B-cell lymphomas (MZL), with head and trunk predominance (median age = 54 years). Relapses in other mucosa-related sites occurred in 3 patients. Histological transformation implied a more aggressive treatment in 3 cases. A favorable outcome was observed in most cases. 9 (20%) diffuse large B-cell lymphomas (DLBCL) appeared as a unique nodule, with female predominance (median age = 74 years) and 4 lymphoma-related deaths which seemed age-related (>70 years) with only one lower limb localization. Histological aggressive features were present in 3 patients with a fatal outcome. 2 (5%) WHO grade 3 follicular lymphomas (FL) had an heterogeneous phenotype, with head localization, cutaneous relapses and good outcome. Conclusions MZL, the predominant type, has a good prognosis, although transformation can occur, needing a more aggressive treatment. DLBCL, observed in older patients, has clinical and histological prognostic factors identical to extra-cutaneous lymphomas. FL appears rare and has an heterogeneous phenotype. Relationships with its nodal counterpart remains unclear.Annales de Pathologie 02/2005; 25(1):8-17. DOI:10.1016/S0242-6498(05)80094-X · 0.29 Impact Factor