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Effects of quercetin on liver damage in rats with carbon tetrachloride-induced cirrhosis

ULBRA-Cachoeira do Sul e Canoas, Brasil.
Digestive Diseases and Sciences (Impact Factor: 2.55). 05/2003; 48(4):824-9. DOI: 10.1023/A:1022869716643
Source: PubMed

ABSTRACT Flavonoids are reported to exhibit a wide variety of biological effects, including antioxidant and free radical-scavenging activities. Evidence of oxidative reactions is often associated with various chronic disease processes characterized by accumulation of connective tissue. This study was aimed to investigate the protective effects of chronic administration of the flavonoid quercetin (150 micromol/kg body wt/day intraperitoneally) in rats with carbon tetrachloride-induced fibrosis. In animals rendered cirrhotic by administration of carbon tetrachloride for 16 weeks, cell necrosis, fibrosis, and inflammatory infiltration were found. Histological abnormalities were accompanied by a higher hepatic content of collagen and thiobarbituric acid-reactive substances. Expression of inducible nitric oxide synthase (iNOS) was significantly increased in the liver. Treatment with quercetin during 3 weeks improved liver histology and reduced collagen content, iNOS expression, and lipid peroxidation. Those effects were associated with an increased total peroxyl radical-trapping antioxidant capacity of liver. We conclude that quercetin is effective in this model of liver damage.

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    • "The most abundant flavonols in onions are derivatives of quercetin, mainly quercetin 4′-O-glucoside and quercetin 3,4′-O-diglucoside (González-Peña et al., 2013). Quercetin has been associated to reduction of lipids in hepatic tissue and hyperlipidaemia in obese mice induced by an atherogenic diet (Park, Ahn, Kim, & Ha, 2008) through oxidation of fatty acids (Czeczot, 2000) and also showing hepatoprotective effects (Cipak, Novotny, Cipakova, & Rauko, 2003; Le Marchand, Murphy, Hankin, Wilkens, & Kolonel, 2000; Pavanato et al., 2003; Peres et al., 2000). Despite these positive effects on lipid metabolism, very little information is available on the role of Allium spices in fatty acid composition and lipid metabolism. "
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    • "Main constituents of the C. arvensis are Quercetin, Kaempferol (Kaur and Kalia, 2012). Quercetin is flavonoid and it is reported to be hepatoprotective (Pavanato et al., 2003). Therefore the hepatoprotective action of the C. arvensis might be due to the hepatoprotective constituents present in it. "
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