Genome function and nuclear architecture: from gene expression to nanoscience.

The Jackson Laboratory, Bar Harbor, Maine 04609, USA.
Genome Research (Impact Factor: 13.85). 07/2003; 13(6A):1029-41. DOI: 10.1101/gr.946403
Source: PubMed

ABSTRACT Biophysical, chemical, and nanoscience approaches to the study of nuclear structure and activity have been developing recently and hold considerable promise. A selection of fundamental problems in genome organization and function are reviewed and discussed in the context of these new perspectives and approaches. Advancing these concepts will require coordinated networks of physicists, chemists, and materials scientists collaborating with cell, developmental, and genome biologists.

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