Article

Simple synthesis of novel diphenylsulfapyrimidine acetates from chalcones and their antimicrobial activity.

Chemistry Department, Faculty of Science, Benha University, Benha, Egypt.
Folia Microbiologica (impact factor: 0.68). 02/2003; 48(1):51-5. pp.51-5
Source: PubMed

ABSTRACT Given the significant low yield (19-43%) in reported results on the cyclocondensation of sulfaguanidine acetate with chalcones, a careful reinvestigation was carried out. A new series of chalcones, bearing electron-attracting groups in the aromatic moiety, have been used as precursors in the synthesis of diphenylsulfapyrimidine acetates with good yield. All synthesized compounds were active against G(+)- and G(-)-bacteria, and fungi. Combination of substituents (Cl, OMe, NO2, etc.) enhanced antimicrobial activity. Derivative with two NO2 groups exhibits an activity comparable with sulfadiazine.

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Keywords

aromatic moiety
 
careful reinvestigation
 
Cl
 
cyclocondensation
 
Derivative
 
G(-)-bacteria
 
good yield
 
new series
 
OMe
 
significant low yield
 
sulfaguanidine acetate
 
synthesized compounds