Endocrine function in patients treated for carcinoma in situ in the testis with irradiation.
ABSTRACT CIS is found in the contralateral testis in 5% of the patients with testicular germ cell cancer. The management of CIS in the contralateral testis is important because the majority - if not all - cases of CIS will progress to invasive disease without treatment. It is well documented that testicular irradiation with a total dose of 14-20 Gy (2 Gy x 7-10) is an effective and safe treatment for CIS in the contralateral testis in patients with unilateral testicular germ cell cancer. However few relapses of testicular cancer have been observed in testis treated with these regimens and the data on 14 Gy are sparse. One study has indicated that more radiotherapy with lower doses per fraction could be useful, but more data are needed to confirm this. Endocrine testicular function has been shown to be impaired already before treatment in patients with CIS and is further impaired after testicular irradiation with 14-20 Gy (2 Gy x 7-10) and only minor dose dependency is seen in the impairment of Leydig cell function. The optimal treatment of CIS in the contralateral testicle in patients orchidectomised for testicular cancer seems to be local radiotherapy of the testis with CIS in order to preserve at least a part of the Leydig cell function. However, the optimal dose level has to be defined.
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ABSTRACT: Conservative surgical management of testicular cancer concerns the rare cases of bilateral tumours or unique functional testis. The objective is to preserve endocrine function of the testis to avoid the need for androgen replacement therapy. Conservative surgery may also preserve paternity when effective spermatogenesis is maintained in the remaining testicular parenchyma. This approach requires complete resection of the tumour associated with biopsies around the tumour to detect any intraepithelial germ cell neoplasia, present in 90% of cases. These radiosensitive lesions can lead to a testicular germ cell tumour in 50 to 70% of cases and therefore require prophylactic treatment by scrotal radiotherapy, which does not appear to compromise testosterone production by testicular Leydig cells.Progrès en Urologie - FMC 09/2008; 18(3):F11–F14. · 0.77 Impact Factor
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ABSTRACT: Effects of gamma rays on the sex steroid hormone levels [testosterone (T), 11-ketotestosterone (11-KT) and 17β-estradiol (E2)] were studied in the freshwater fish Oreochromis mossambicus. Gamma radiation induced effects on hormone levels reported here for the first time in the fish. Since radionuclides released accidentally or during a nuclear disaster can contaminate inland water bodies, biomonitoring methods are required for assessing the impacts of certain dose levels of radiation that may ultimately result in ionizing radiation exposure to both humans and non-human biota. Three groups of (n=15 in each group) fishes were irradiated with a single dose of 60Co 10 Gy, 15 Gy and 20 Gy with a duration of .33, .50 and .66 min. Significant decrease of the hormone levels was seen at higher doses of 15 Gy and 20 Gy. The sex steroid hormone levels in the fishes are vital for sperm production, development, differential functions related to the physiology and reproductive behavior. This study serves as biomonitoring tool to assess the ionizing radiation effects on reproductive behavior of aquatic biota.Ecotoxicology and Environmental Safety 03/2014; 101:103–106. · 2.48 Impact Factor