Effect of the desert plant Retama raetam on glycaemia in normal and streptozotocin-induced diabetic rats
UFR Physiology of the Nutrition and Endocrinian Pharmacology, Faculty of Sciences and Techniques Errachidia, Boutalamine, B.P. 509, Errachidia, Morocco. Journal of Ethnopharmacology
(Impact Factor: 3).
08/2003; 87(1):21-5. DOI: 10.1016/S0378-8741(03)00104-1
The effect of the aqueous extract of Retama raetam (RR) on blood glucose levels was investigated in fasting normal and streptozotocin-induced diabetic rats after single and repeated oral administration. The aqueous extract of RR at a dose of 20mg/kg significantly reduced the blood glucose in normal rats 6h after a single oral administration (P<0.005) and two weeks after repeated oral administration (P<0.05). This hypoglycaemic effect is more pronounced in streptozotocin (STZ) diabetic rats (P<0.001). The aqueous extract of RR had no effect on basal plasma insulin levels indicating that the underlying mechanism of RR activity is extra-pancreatic. These findings suggest that the aqueous extract of RR possess significant hypoglycaemic effect in both normal and STZ diabetic rats.
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