Evaluation of efficacy and safety of a herbal medicine used for the treatment of malaria.
ABSTRACT Resistance of Plasmodium falciparum to chloroquine has been reported in several countries. Other anti-malarial drugs in use are expensive and not readily accessible to most people in malaria endemic countries. This has led to renewed interest in the development of herbal medicines that have the potential to treat malaria with little or no side effects. This study obtained a preliminary information on the safety and effectiveness of a plant decoction (AM-1), used in treating malaria. The AM-1 is formulated from Jatropha curcas, Gossypium hirsutum, Physalis angulata and Delonix regia. Patients with suspected malaria attending a herbal clinic were enrolled in the study on voluntary basis. They were hospitalized for treatment, clinical observation, biochemical and haematological monitoring, and parasite clearance while on AM-1. In addition male and female Sprague Dawley rats were used to evaluate the acute and subchronic toxicity effects of AM-1. The AM-1 eliminated malaria parasites (Plasmodium falciparum and Plasmodium malarie) from the peripheral blood of patients with malaria. In addition the AM-1 did not show any undesired effects in the patients as well as in laboratory rats. The AM-1, however, showed differential effect on the activities of selected cytochrome P450 isozymes (7-pentoxyresorufin-O-depentylation, 7-ethoxyresorufin-O-deethylation and p-nitrophenol hydroxylase) in relation to sex of the laboratory rats. These results indicate that AM-1 could be used to treat malaria. However, it could precipitate interactions with other drugs via their biotransformation and elimination. The obtained data warrant further studies in a large number of malaria subjects with monitoring for possible drug interactions.
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ABSTRACT: Physalis angulata L., an annual herb from the Solanaceae family, is widely used in popular medicine in tropical countries to treat a variety of diseases. Two products, (X) and (Y), were isolated from a crude CH2Cl2 extract of dried Congolese Physalis angulata L. plants and crystallized from acetone for structure elucidation. Compound (X) corresponds to a physalin B dimer acetone solvate hydrate (2C28H30O9·C3H6O·0.22H2O), while compound (Y) crystallizes as a mixed crystal containing two physalin B molecules which overlap with 5β,6β-epoxyphysalin B, also known as physalin F, and one acetone molecule in the asymmetric unit (1.332C28H30O9·0.668C28H30O10·C3H6O). Antiplasmodial activity, cytotoxic activity and selectivity indices were determined for crude extracts and the two isolated products (X) and (Y).Acta Crystallographica Section C Crystal Structure Communications 12/2013; 69(Pt 12):1557-62. · 0.78 Impact Factor
- Studies in Surface Science and Catalysis - STUD SURF SCI CATAL. 01/2001; 135:228-228.
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ABSTRACT: Historians of the Atlantic slave trade have argued that the inhabitants of the Gold Coast of West Africa participated in a system of cultural and material exchange during the seventeenth and eighteenth centuries that resulted in the diffusion and syncretism of ideas and practices. This position presumes that the cultures of the Gold Coast were transformed by centuries of contact with the peoples of the Atlantic Rim. Despite the intensive commercial contact between Europeans and Africans during this period, the exchange of medical ideas, healing practices, and medical material cultures was limited by both the disease environment of West Africa and by the cultural chauvinism of surgeons and healers. This article will demonstrate the necessity of investigating local and particular changes to cultures before conjecturing about the larger outcomes of trans-Atlantic exchange.Canadian Journal of African Studies/La Revue canadienne des études africaines. 08/2012; 45(3).