Article

Impact of antidiabetic medications on physical and cognitive functioning of older Mexican Americans with diabetes mellitus: A population based cohort study

University of Michigan, School of Public Health, Epidemiology, Ann Arbor, MI 48109, USA.
Annals of Epidemiology (Impact Factor: 2.15). 05/2003; 13(5):369-76. DOI: 10.1016/S1047-2797(02)00464-7
Source: PubMed

ABSTRACT The current study was designed to evaluate the utility of antidiabetic medications in affecting changes in physical and cognitive functioning among older Mexican Americans with diabetes over a 2-year period.
A longitudinal analysis with repeated measurements between 1999 and 2001 was performed in a cohort of Mexican Americans, 60 or older, in the SALSA Project. Statistical analysis was conducted using a generalized estimating equation.
For subjects with diagnosed diabetes </= 5 years (N = 381), there was less decline in physical and cognitive functioning over 2 years among subjects on treatment, compared to those without treatment. For subjects with diagnosed diabetes of 5+ years (N = 337), the effect of antidiabetic medications was more significant in preventing the decline in physical and cognitive functioning (ADL: mean in log scale = -0.10, 95% CI = -0.16, -0.04, 3MS: mean = 6.35, 95% CI = 3.23, 9.48). Combination therapy of antidiabetic agents appeared to be more effective than monotherapy in preventing the decline in physical and cognitive functioning for subjects.
Antidiabetic drugs appear to be useful in alleviating the decline in physical and cognitive functioning among older Mexican Americans with diabetes, especially for those with a longer duration of the disease.

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    • "To minimize diabetes-related declines in cognitive functioning, older adults with diabetes should monitor their diabetes and adhere to treatment regimens [43]. It has been suggested that, in comparison with people with diabetes who do not adhere to their treatment regimen, cognitive decline is less in people adhering to either a monotherapy (use of sulfonylurea, metformin, or thiazolidinedione) or combination (sulfonylurea with another glucose-lowering agent, insulin, or metformin and insulin) [2,43], but other research does not support this finding with people who are using short-term glycemic control.[20] "
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