Synchronous multiple glomus tumors of the esophagus and lung.
ABSTRACT A case of synchronous esophageal and multiple pulmonary tumors presenting complex diagnostic problems is described. In the course of routine pulmonary screening a pulmonary coin lesion of the right lung and three very small foci on the left side, under the pleura falling just within the range of diagnostic parameters was identified in a symptom-free patient. In addition to the multiple lung lesions a single sub-mucosal esophageal tumor was detected. Following minimally invasive surgical excision of the tumors the precise nature of the neoplasms was determined by means of comparative histological, light-and electro-microscopic as well as immunohistochemical studies. The earlier diagnosis of carcinoid was reviewed, rejected and glomus tumor was confirmed. Multiple glomus tumors of the above localizations have not been previously described in the literature.
- SourceAvailable from: Mladen Belicza[Show abstract] [Hide abstract]
ABSTRACT: We report a case of glomangioma of the esophagus in a 28-year-old woman who presented with a 3-year history of vague discomfort, pain and heat in the neck. At initial gross examination, the tumor mimicked an esophageal papilloma. The resected esophageal specimen contained a polypoid, whitish-gray mass, which measured 3 cm in maximum diameter. Microscopically the tumor consisted of loose fibrovascular stroma heavily infiltrated with mononuclear inflammatory cells and covered with focally hyperkeratotic, parakeratotic and acanthotic squamous epithelium without atypia. In the deeper area immediately above the true muscular layer of the esophageal wall, microscopical examination revealed the neoplasm consisting of numerous, small-to-medium branched vessels covered by regular endothelium and filled with erythrocytes. The loose stroma around the vessels contained poorly circumscribed nests of small, round to oval cells with a uniform appearance. Immunohistochemically, the tumor cells were immunoreactive for smooth muscle actin and vimentin and non-immunoreactive for CD34, CD117, desmin, pan-cytokeratin, synaptophisin, neuron-specific enolase and S-100 protein. Despite its bland histology, the infiltrative growth pattern was suggestive of aggressive behavior; thus, an appropriate clinical follow-up was recommended. An accurate diagnosis and an understanding of the behavior of these rare tumors, especially in an unusual location, are crucial to their management and clinical outcome.Diseases of the Esophagus 02/2006; 19(3):208-11. DOI:10.1111/j.1442-2050.2006.00568.x
Article: Glomus Tumor of the Index Finger[Show abstract] [Hide abstract]
ABSTRACT: A 41-year-old female patient presented with localized worsening subungual pain of her right index finger. Subsequent diagnostic evaluation revealed the presence of a glomus tumor. A glomus tumor is a rare tumor with a predilection for the hand. Classic symptoms include pain, pain with pressure, and pain with cold temperature. We present a completely updated literature review that addresses the epidemiology, pathology, presentation, diagnostic evaluation, classification, histology, genetics, and treatment options for glomus tumors.Journal of Craniofacial Surgery 08/2006; 17(4):801-4. DOI:10.1097/00001665-200607000-00037
- Journal of Clinical Pathology 10/2006; 59(9):1000. DOI:10.1136/jcp.2005.031237