Association of consumption of products containing milk fat with reduce asthma risk in pre-school children: The PIAMA birth cohort study

University of Groningen, Groningen, Groningen, Netherlands
Thorax (Impact Factor: 8.56). 08/2003; 58(7):567-72. DOI: 10.1136/thorax.58.7.567
Source: PubMed

ABSTRACT Environment and lifestyle contribute to the development of asthma in children. Understanding the relevant factors in this relationship may provide methods of prevention. The role of diet in the development of asthma in pre-school children was investigated.
Data from 2978 children participating in a prospective birth cohort study were used. Food frequency data were collected at the age of 2 years and related to asthma symptoms reported at the age of 3 years.
The prevalence of recent asthma at age 3 was lower in children who consumed (at age 2) full cream milk daily (3.4%) than in those who did not (5.6%) and in those who consumed butter daily (1.5%) than in those who did not (5.1%). The prevalence of recent wheeze was lower in children who consumed milk products daily (13.7%) than in those who did not (18.4%) and in children who consumed butter daily (7.7%) than in those who did not (15.4%). These effects remained in a logistic regression model including different foods and confounders (adjusted odds ratio (CI) for recent asthma: full cream milk daily v rarely 0.59 (0.40 to 0.88), butter daily v rarely 0.28 (0.09 to 0.88)). Daily consumption of brown bread was also associated with lower rates of asthma and wheeze, whereas no associations were observed with the consumption of fruits, vegetables, margarine, and fish.
In pre-school children, frequent consumption of products containing milk fat is associated with a reduced risk of asthma symptoms.

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    • "An increase in the ratio of dietary polyunsaturated fatty acids (PUFAs) to saturated fatty acids (SFA), named P/S ratio, has been observed in westernized diet over the last few decades [1] [5] [6]. This event is associated with asthma susceptibility, as demonstrated by some studies that related consumption of PUFA with higher, and consumption of SFA with lower susceptibility to asthma [7] [8] [9] [10]. It was hypothesized that an increase in n-6 PUFA/n-3 PUFA ratio, instead of the increase in P/S ratio, could raise the susceptibility to the development of asthma [5], but this hypothesis is not supported by epidemiological studies [1]. "
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    ABSTRACT: The prevalence of asthma has risen over the last few decades, and some studies correlate this with the greater consumption of polyunsaturated fatty acids (PUFAs). Dietary PUFAs are known to increase the susceptibility of biological structures to lipid peroxidation, a process by which platelet-activating factor (PAF)-like lipids can be generated. These lipids functionally mimic the bioactivity of PAF, a potent proinflammatory mediator that exerts several deleterious effects on asthma. Thus, this work aimed to investigate if dietary supplementation with soybean lecithin (SL), a source of PUFAs, increases lipid peroxidation and PAF bioactivity in lungs of asthmatic Wistar rats. Animals were separated into groups: control, supplemented, asthmatic, asthmatic supplemented with SL (2 g/kg body weight), asthmatic supplemented with SL (2 g/kg body weight) and DL-alpha-tocopheryl acetate (100 mg/kg body weight). Asthmatic inflammation increased pulmonary lipid peroxidation, PAF bioactivity, alveolar-capillary barrier permeability and production of nitric oxide. In asthmatics, dietary supplementation with SL promoted an increase in pulmonary lipid peroxidation and PAF bioactivity, and an increase in the permeability of the alveolar-capillary barrier. Moreover, the treatment of asthmatic rats with DL-alpha-tocopheryl acetate inhibited the lipid peroxidation and decreased the PAF bioactivity. Therefore, the increase in pulmonary PAF bioactivity in asthmatic individuals elicited by the dietary supplementation with SL probably involves the generation of PAF-like lipids. This finding suggests that PAF-like lipids may account for the deleterious effects of dietary PUFAs on asthma.
    The Journal of nutritional biochemistry 05/2009; 21(6):532-7. DOI:10.1016/j.jnutbio.2009.03.001 · 4.59 Impact Factor
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    • "Various studies have attempted to dissect how diet might affect allergic inflammation in human populations. A Dutch study showed that children given full fat dairy products early in life had decreased incidence of later allergies compared to those given skimmed milk products (Wijga et al., 2003). High-fat diet was reported to increase life-time incidence of asthma in a Swedish study (Strom et al., 1996). "
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    ABSTRACT: In this review we focus on dietary fat content and subsequent effects on asthma. According to the World Health Organisation over 300 million people currently have asthma. The majority of asthma cases are 'extrinsic' and result from inappropriate 'allergic' immune responses to inhaled environmental substances. Whilst some individuals are allergic to particular food components it is becoming clear that the content of the diet can more generally affect the health of the immune system. Components of maternal and early life diets have been reported to influence offspring immune function and asthma. There has been speculation that different types of dietary fat have pro- and anti-inflammatory effects but the results of various studies are contradictory. Asthma and obesity are two conditions that have almost simultaneously reached epidemic levels in some societies. There is evidence that diet-induced obesity alters immune function and there is little doubt that consumption of a high caloric diet with high fat content leads to obesity. However, there is conflicting information over whether and how obesity is linked to asthma in children and adults. Whilst obesity is to be avoided there is accumulating evidence that dietary fat per se does not necessarily predispose towards allergic symptoms.
    Pharmacology [?] Therapeutics 03/2009; 122(1):78-82. DOI:10.1016/j.pharmthera.2009.02.001 · 7.75 Impact Factor
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    • "Dietary studies have indicated a protective effect of butter relative to margarine against allergy and asthma (Bolte et al. 2001; Dunder et al. 2001; Woods et al. 2003). Similarly, a 3-year prospective cohort study found a decreased risk of asthma in children who consumed full cream milk and butter daily, compared to those who did not (Wijga et al. 2003). Since butter is normally rich in CLA, this might suggest a positive effect of CLA on the prevention of those diseases. "
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