Article

Hypocholesterolemic activity of hesperetin derivatives.

Korea Research Institute of Bioscience and Biotechnology, 52 Oun, Yusong, Taejon 305-333, Republic of Korea.
Bioorganic & Medicinal Chemistry Letters (impact factor: 2.55). 09/2003; 13(16):2663-5. pp.2663-5
Source: PubMed

ABSTRACT Hesperetin ester and ether derivatives possessing a long alkyl chain were synthesized for examining their hypocholesterolemic activities in high cholesterol-fed mice. Hesperetin 7-O-lauryl ether (4b) and hesperetin 7-O-oleyl ether (4e) exhibited strong cholesterol-lowering effects.

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Keywords

cholesterol-fed mice
 
Hesperetin 7-O-lauryl ether
 
hesperetin 7-O-oleyl ether
 
Hesperetin ester
 
hypocholesterolemic activities
 

Tae-Sook Jeong