The BON domain: a putative membrane-binding domain

The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK CB10 1SA.
Trends in Biochemical Sciences (Impact Factor: 13.52). 08/2003; 28(7):352-5. DOI: 10.1016/S0968-0004(03)00115-4
Source: PubMed

ABSTRACT A novel conserved protein region – the BON (bacterial OsmY and nodulation) domain – is found in the bacterial osmotic-shock-resistance protein OsmY, a family of haemolysins, a group of nodulation specificity proteins and secretory channels, and several hypothetical proteins. Functional annotation in the literature suggests that it interacts with phospholipid membranes. A lack of catalytic residues in the sequence alignment supports the hypothesis that it is a binding domain.

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