Article

Glycolysis and pyruvate oxidation in cardiac hypertrophy--why so unbalanced?

McDonald Research Laboratories/The iCAPTUR4E Centre, Department of Pathology and Laboratory Medicine, University of British Columbia, St. Paul's Hospital, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6.
Comparative Biochemistry and Physiology - Part A Molecular & Integrative Physiology (impact factor: 2.23). 09/2003; 135(4):499-513. pp.499-513
Source: PubMed

ABSTRACT Cardiac hypertrophy, induced by chronic pressure or volume overload, is associated with abnormalities in energy metabolism as well as characteristic increases in muscle mass and alterations in the structure of the heart. Hypertrophied hearts display increased rates of glycolysis and overall glucose utilization, but rates of pyruvate oxidation do not rise in step with rates of pyruvate generation. Glycolysis and glucose oxidation, therefore, become markedly less 'coupled' in hypertrophied hearts than in non-hypertrophied hearts. Because the pyruvate dehydrogenase complex (PDC) contributes so powerfully to the control of glucose oxidation, we set out to test the hypothesis that the function of PDC is impaired in cardiac hypertrophy. In this review we describe evidence indicating that the alterations in glucose metabolism in hypertrophied hearts cannot be explained simply by changes in PDC expression or control. Additional mechanisms that may lead to an altered balance of pyruvate metabolism in cardiac hypertrophy are discussed, with commentaries on possible changes in pyruvate transport, NADH shuttles, lactate dehydrogenase, and amino acid metabolism.

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Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

Additional mechanisms
 
amino acid metabolism
 
cardiac hypertrophy
 
characteristic increases
 
energy metabolism
 
glucose metabolism
 
glucose oxidation
 
hypertrophied hearts
 
Hypertrophied hearts display
 
lactate dehydrogenase
 
markedly less 'coupled'
 
muscle mass
 
non-hypertrophied hearts
 
PDC expression
 
pyruvate dehydrogenase complex
 
pyruvate generation
 
pyruvate metabolism
 
pyruvate oxidation
 
pyruvate transport
 
rates