Cutaneous fibropapilloma in a cat (feline sarcoid).
Department of Pathology and Microbiology, Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward Island C1A 4P3.The Canadian veterinary journal. La revue veterinaire canadienne (Impact Factor: 0.47). 08/2003; 44(7):601-2.
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Article: Auricular rhabdomyosarcoma in a rat.[Show abstract] [Hide abstract]
ABSTRACT: An ear (auricular) neoplasm from a 1-year-old male rat was removed surgically and examined histologically. Macroscopically, the neoplasm was firm, white and measured (0.5 x 0.5 cm). Microscopically, the neoplasm was expansile, non-encapsulated, and composed of large, pleomorphic, polygonal to spindle-shaped cells containing multiple nuclei. Using immunohistochemical and chemical stains, the neoplastic cells were positive for vimentin, myoglobin, phosphotungstic acid haematoxylin and desmin, but had no immunoreactivity for cytokeratin or alpha-smooth muscle actin. On the basis of histopathological, immunohistochemical and histochemical stains, a diagnosis of auricular rhabdomyosarcoma was made. Although reported infrequently in human, this is, to the author's knowledge, the first report that describes the detailed gross, histopathological, histochemical and immunohistochemical findings of auricular rhabdomyosarcoma in a rat.Journal of Veterinary Medicine Series A 07/2006; 53(5):246-8. DOI:10.1111/j.1439-0442.2006.00829.x · 0.93 Impact Factor
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ABSTRACT: Fibropapilloma of the penis is caused by the bovine papillomavirus. Two 12- and 18-month-old bulls were presented with a history of gradually enlarging mass on the glans of penis. Grossly, the masses were multinodular proliferations, of varied sizes mainly between 0.5 and 5cm in diameter, well circumscribed, and nonpigmented and were attached to the glans by a relatively broad pedicle. Histopathologically, the masses were papillomatous features with irregular hyperplasia and epidermal rete ridges. The dermis consisted of densely packed irregular collagenous connective tissue with many fibroblasts. In the epidermis, orthokeratotic hyperkeratosis, many koilocytes with variably sized keratohyalin granules, and rare presence of intranuclear inclusion bodies were present. The morphologic patterns were typical of fibropapillomas of papillomavirus etiology. In one case, recurrence of lesion occurred about 2months after surgical treatment.Comparative Clinical Pathology 08/2008; 18(3):261-263. DOI:10.1007/s00580-008-0783-6
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ABSTRACT: Rudolph Virchow first speculated on a relationship between inflammation and cancer more than 150 years ago. Subsequently, chronic inflammation and associated reactive free radical overload and some types of bacterial, viral, and parasite infections that cause inflammation were recognized as important risk factors for cancer development and account for one in four of all human cancers worldwide. Even viruses that do not directly cause inflammation can cause cancer when they act in conjunction with proinflammatory cofactors or when they initiate or promote cancer via the same signaling pathways utilized in inflammation. Whatever its origin, inflammation in the tumor microenvironment has many cancer-promoting effects and aids in the proliferation and survival of malignant cells and promotes angiogenesis and metastasis. Mediators of inflammation such as cytokines, free radicals, prostaglandins, and growth factors can induce DNA damage in tumor suppressor genes and post-translational modifications of proteins involved in essential cellular processes including apoptosis, DNA repair, and cell cycle checkpoints that can lead to initiation and progression of cancer.Journal of Veterinary Internal Medicine 12/2011; 26(1):18-31. DOI:10.1111/j.1939-1676.2011.00836.x · 2.22 Impact Factor