Amoxicillin-induced acute renal failure.

Department of Anesthesiology and Operative Intensive Care Medicine, University Hospital Charité, Campus Virchow Clinic, Berlin, Germany.
Nephrology Dialysis Transplantation (Impact Factor: 3.58). 09/2003; 18(8):1660-2.
Source: PubMed
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    • "Liver toxicity is rare with the use of diclofenac, and the short term use of diclofenac does not cause kidney toxicity [21]. However, amoxicillin is known to cause liver and kidney failure, albeit infrequently [22,23]. In the present study, as there were no cases of significant liver or kidney failure, we hypothesized that the drugs (anesthetics and antibiotics) used during anesthesia had no effect on liver or kidney function. "
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    ABSTRACT: Inhalation anesthetics are an important factor for postoperative hepatic and renal dysfunction. In this regard, TIVA can reduce the risk of hepatic and renal dysfunction inherited to inhalation anesthetics. The present study was conducted to determine whether hepatic and renal functions differ after anesthesia with sevoflurane and propofol. Two hundred patients, ASA physical status class I, II, scheduled for an elective thyroidectomy were randomly divided into two groups. Anesthesia was maintained with sevoflurane 1-2% and remifentanil in the sevoflurane group (Group S) and propofol 2-5 ug/ml and remifentanil 2-5 ng/ml at the effect site, using a target controlled infusion (TCI) pump in the TIVA group (Group T) to maintain BIS of 40-60. To evaluate the hepatic and renal function, aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN) and creatinine were tested at preoperation (baseline), postoperative 1 day and 3 days. AST was increased at postoperative 1 day and 3 days, compared with that of the preoperation in Group S, and postoperative 1 day in Group T, but the values were within its normal limit. ALT was not changed after anesthesia in both groups. BUN was increased at postoperative 1 day, compared with that of the preoperation in Group S, but the value was within its normal limit. Creatinine was not changed after anesthesia in both groups. The changes of hepatic and renal function after inhalation anesthesia with sevoflurane and TIVA with propofol and remifentanil for thyroidectomy were clinically insignificant, and there was no difference between the two methods.
    Korean journal of anesthesiology 02/2013; 64(2):112-6. DOI:10.4097/kjae.2013.64.2.112
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    ABSTRACT: Beta-lactam-associated acute tubulointerstitial nephritis (ATIN) is a rare condition in childhood. We report the case of an infant with penicillin-associated ATIN and concomitant acute pyelonephritis resulting in the development of severe acute kidney injury (AKI). The treatment consisted of penicillin suspension and appropriate AKI management, which required a short period of dialysis. Finally, full recovery and normalization of laboratory parameters occurred. We present here the first case of oral penicillin-associated ATIN in childhood. © 2015 Japan Pediatric Society.
    Pediatrics International 02/2015; 57(2). DOI:10.1111/ped.12571 · 0.73 Impact Factor

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