Article

Rapid evolution of male-biased gene expression in Drosophila

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
Proceedings of the National Academy of Sciences (Impact Factor: 9.81). 09/2003; 100(17):9894-9. DOI: 10.1073/pnas.1630690100
Source: PubMed

ABSTRACT A number of genes associated with sexual traits and reproduction evolve at the sequence level faster than the majority of genes coding for non-sex-related traits. Whole genome analyses allow this observation to be extended beyond the limited set of genes that have been studied thus far. We use cDNA microarrays to demonstrate that this pattern holds in Drosophila for the phenotype of gene expression as well, but in one sex only. Genes that are male-biased in their expression show more variation in relative expression levels between conspecific populations and two closely related species than do female-biased genes or genes with sexually monomorphic expression patterns. Additionally, elevated ratios of interspecific expression divergence to intraspecific expression variation among male-biased genes suggest that differences in rates of evolution may be due in part to natural selection. This finding has implications for our understanding of the importance of sexual dimorphism for speciation and rates of phenotypic evolution.

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Available from: Jose Ranz, Aug 01, 2014
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    • "In support of this theory, genes that are male-biased in their expression show greater divergence between species compared to female-biased and non-biased genes (Civetta and Singh, 1995; Meiklejohn et al., 2003; Hearty et al., 2007, but see Metta et al., 2006 for a counter example). In addition, spermatogenesis is considered to be more easily disrupted by mutations than oogenesis , leading to more male than female hybrid sterility (Wu and Davis, 1993). "
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    Frontiers in Genetics 05/2015; 6. DOI:10.3389/fgene.2015.00140
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    • "Sex-biased gene expression is a common phenomenon in both dioecious plant and animal species, as documented in humans (Dimas & Nica, 2012), Drosophila (Zhang et al., 2007), emus (Vicoso et al., 2013) and Silene latifolia (Zemp et al., 2014), among others. Genes that exhibit sex-biased expression might be under unique evolutionary constraints, evolving more rapidly in terms of both sequence and expression (Meiklejohn et al., 2003). "
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    • "Divergence of the regulatory networks controlling gene expression can cause misexpression in F 1 hybrids that can contribute to speciation (Meiklejohn et al. 2003; Michalak and Noor 2004; Ranz et al. 2004; Haerty and Singh 2006; Moehring et al. 2007; Maheshwari and Barbash 2012). This can occur, for example, when proteins and/or DNA with sequence-specific interactions coevolve such that divergent alleles of the interacting molecules do not function properly together in F 1 hybrids. "
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