Article

[Functional evaluation for neural progenitor cells transplantation to treat spinal cord injury in rats].

Department of Orthopedics, Peking University Third Hospital, Beijing 100083, China.
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 07/2003; 35(3):274-6.
Source: PubMed

ABSTRACT To evaluate the functional recovery of acute spinal cord-injured rats treated by immortalized neural progenitor cells transplantation.
Spinal cord injury (SCI) model was built by revised Allen method. Immortalized neural progenitor cells (G3 line) transplantation was performed on day 9 after injury. Culture medium and nontreatment groups were used as control. BBB scores were checked every week to show the motor function recovery and Motor Evoked Potentials (MEPs) were recorded 8 and 12 weeks after transplantation to display the conduction of injured spinal cord.
There were not significantly differences for BBB scores among the three groups within 12 weeks after grafting; but MEPs were significantly enhanced in G3 group compared with control and sham groups.
Immortalized neural progenitor cells transplantation can significantly improve the conduction of spinal cord injured rats.

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Keywords

acute spinal cord-injured rats
 
Allen method
 
BBB scores
 
Culture medium
 
day 9
 
functional recovery
 
G3 group
 
G3 line
 
Immortalized neural progenitor cells
 
immortalized neural progenitor cells transplantation
 
Motor Evoked Potentials
 
motor function recovery
 
nontreatment groups
 
sham groups
 
spinal cord
 
Spinal cord injury
 
three groups
 
transplantation