Article

Bicuculline infusion into the accessory olfactory bulb facilitates the induction of maternal behavior in rats.

Dept. de Psicobiología, Univ. Nacional de Educación a Distancia, Madrid, Spain Area 11, IMSALUD, Madrid, Spain.
Scandanavian Journal of Psychology (impact factor: 1.52). 08/2003; 44(3):273-7. pp.273-7
Source: PubMed

ABSTRACT The GABAA antagonist bicuculline, intracranially infused into the accessory olfactory bulb (AOB), facilitated the expression of maternal behavior (MB) in virgin Wistar female rats. Behavioral effects were observed 24 hours after infusion and were injection dependent. Pheromonal stimuli, generated by the pups, are thought to exert an inhibitory effect on vomeronasal nuclei involved in MB in virgin rats. The present study investigated the possibility that a decrement in AOB output, resulting from long-term compensatory synaptic changes to chronic bicuculline infusion, would facilitate the expression of MB. The implications of our findings for the mechanisms involved in the induction of MB and the maternal experience effect are discussed.

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Keywords

accessory olfactory bulb
 
AOB output
 
Behavioral effects
 
chronic bicuculline infusion
 
GABAA antagonist bicuculline
 
implications
 
induction
 
infusion
 
inhibitory effect
 
injection dependent
 
long-term compensatory synaptic changes
 
maternal behavior
 
maternal experience effect
 
Pheromonal stimuli
 
virgin Wistar female rats