Antibodies to Dopamine as Neuromodulators of Behavioral Responses of Mice of Different Genotypes

Science Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
Neuroscience and Behavioral Physiology 07/2003; 33(5):507-12. DOI: 10.1023/A:1023471402939
Source: PubMed


The possibility of long-term changes in the innate characteristics of the behavior of mice of different genotypes (C57Bl/6 and BALB/c) after active immunization with dopamine-BSA conjugates was studied. These experiments revealed significant differences in the effects of anti-dopamine antibody on behavioral responses in an open field and neurotransmitter contents of brain structures in mice of different lines. Immunization with the dopamine-protein conjugate led to increases in the functional activity of the corresponding brain receptors, to different extents in mice of different lines.

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