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Mizumura S, Kumita S, Cho K, Ishihara M, Nakajo H, Toba M, Kumazaki TDevelopment of quantitative analysis method for stereotactic brain image: assessment of reduced accumulation in extent and severity using anatomical segmentation. Ann Nucl Med 17:289-295

Department of Radiology, Nippon Medical School, Tokyo, Japan.
Annals of Nuclear Medicine (Impact Factor: 1.51). 07/2003; 17(4):289-95. DOI: 10.1007/BF02988523
Source: PubMed

ABSTRACT Through visual assessment by three-dimensional (3D) brain image analysis methods using stereotactic brain coordinates system, such as three-dimensional stereotactic surface projections and statistical parametric mapping, it is difficult to quantitatively assess anatomical information and the range of extent of an abnormal region. In this study, we devised a method to quantitatively assess local abnormal findings by segmenting a brain map according to anatomical structure. Through quantitative local abnormality assessment using this method, we studied the characteristics of distribution of reduced blood flow in cases with dementia of the Alzheimer type (DAT). Using twenty-five cases with DAT (mean age, 68.9 years old), all of whom were diagnosed as probable Alzheimer's disease based on NINCDS-ADRDA, we collected I-123 iodoamphetamine SPECT data. A 3D brain map using the 3D-SSP program was compared with the data of 20 cases in the control group, who age-matched the subject cases. To study local abnormalities on the 3D images, we divided the whole brain into 24 segments based on anatomical classification. We assessed the extent of an abnormal region in each segment (rate of the coordinates with a Z-value that exceeds the threshold value, in all coordinates within a segment), and severity (average Z-value of the coordinates with a Z-value that exceeds the threshold value). This method clarified orientation and expansion of reduced accumulation, through classifying stereotactic brain coordinates according to the anatomical structure. This method was considered useful for quantitatively grasping distribution abnormalities in the brain and changes in abnormality distribution.

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    • "The difference in CMRglc between each patient and this database was expressed as a Z-score (normal mean individual value / normal SD) and superimposed onto 3D-SSP maps (Minoshima et al., 1995). The regional Z-score was examined using the stereotactic extraction estimation (SEE) method developed by (Mizumura et al., 2003) an analytical method for measuring regional Z-scores using a stereotactic region of interest template from the Talairach Daemon database. Using the SEE method, we calculated the extent ratio, which was the percentage of voxels that showed Z-score > 0 in a specific brain area, and we calculated the severity, which was the average of Z-scores of these voxels. "
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    • "In order to evaluate the decrease in the regional cerebral metabolic rate of glucose (CMRglc) in all patients, the CMRglc for each patient was compared using three-dimensional stereotactic surface projection (3D-SSP) analysis with an age-matched normative database consisting of data from 77 normal healthy volunteers between 41 and 84 years of age (36 men and 41 women) [19]. The difference in CMRglc between each patient and this database was expressed as a Z-score (normal mean-individual value/normal SD) and superimposed onto 3D-SSP maps [20] [21]. Hypometabolism in the PVC was measured based on the average extent of CMRglc reduction in each primary visual cortex on the [ 18 F]-FDG PET scans at a Z-score of N1.0. "
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