Mizumura S, Kumita S, Cho K, Ishihara M, Nakajo H, Toba M, Kumazaki TDevelopment of quantitative analysis method for stereotactic brain image: assessment of reduced accumulation in extent and severity using anatomical segmentation. Ann Nucl Med 17:289-295

Department of Radiology, Nippon Medical School, Tokyo, Japan.
Annals of Nuclear Medicine (Impact Factor: 1.51). 07/2003; 17(4):289-95. DOI: 10.1007/BF02988523
Source: PubMed

ABSTRACT Through visual assessment by three-dimensional (3D) brain image analysis methods using stereotactic brain coordinates system, such as three-dimensional stereotactic surface projections and statistical parametric mapping, it is difficult to quantitatively assess anatomical information and the range of extent of an abnormal region. In this study, we devised a method to quantitatively assess local abnormal findings by segmenting a brain map according to anatomical structure. Through quantitative local abnormality assessment using this method, we studied the characteristics of distribution of reduced blood flow in cases with dementia of the Alzheimer type (DAT). Using twenty-five cases with DAT (mean age, 68.9 years old), all of whom were diagnosed as probable Alzheimer's disease based on NINCDS-ADRDA, we collected I-123 iodoamphetamine SPECT data. A 3D brain map using the 3D-SSP program was compared with the data of 20 cases in the control group, who age-matched the subject cases. To study local abnormalities on the 3D images, we divided the whole brain into 24 segments based on anatomical classification. We assessed the extent of an abnormal region in each segment (rate of the coordinates with a Z-value that exceeds the threshold value, in all coordinates within a segment), and severity (average Z-value of the coordinates with a Z-value that exceeds the threshold value). This method clarified orientation and expansion of reduced accumulation, through classifying stereotactic brain coordinates according to the anatomical structure. This method was considered useful for quantitatively grasping distribution abnormalities in the brain and changes in abnormality distribution.

Download full-text


Available from: Sunao Mizumura, Aug 22, 2015
  • Source
    • "The difference in CMRglc between each patient and this database was expressed as a Z-score (normal mean individual value / normal SD) and superimposed onto 3D-SSP maps (Minoshima et al., 1995). The regional Z-score was examined using the stereotactic extraction estimation (SEE) method developed by (Mizumura et al., 2003) an analytical method for measuring regional Z-scores using a stereotactic region of interest template from the Talairach Daemon database. Using the SEE method, we calculated the extent ratio, which was the percentage of voxels that showed Z-score > 0 in a specific brain area, and we calculated the severity, which was the average of Z-scores of these voxels. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Objectives It is well known that Alzheimer's disease (AD)-type pathology is commonly present in dementia with Lewy bodies (DLB) brains and that the degree of AD-type pathology has an influence on the clinical characteristics of DLB. Although significant hypometabolism in the temporoparietal/precuneus on [18F]fluoro-d-glucose (18F-FDG) positron emission tomography (PET) scans is considered to support a diagnosis of AD, some DLB patients also exhibit this metabolic pattern. The clinical significance of the metabolic pattern on DLB remains unknown.Methods Twenty-three DLB patients, 10 AD patients, and 11 controls underwent 18F-FDG PET scans. According to the degree of hypometabolism in the parietal/precuneus regions, representing the AD-like metabolic pattern, 12 patients were placed in the DLB-AD(+) group and 11 patients were placed in the DLB-AD(−) group. The demographics and clinical variables were compared among the four groups.ResultsIn addition to the parietal/precuneus regions, the DLB-AD(+) group exhibited significantly greater posterior cingulate hypometabolism than the DLB-AD(−) group, although occipital metabolism did not differ. The prevalence of visual hallucinations and extracampine hallucinations, and the Bender-Gestalt test score were significantly higher in the DLB-AD(+) group than the DLB-AD(−) group, although there were no differences in the demographics and other examined clinical variables between the two DLB groups. These clinical differences were absent in the DLB-AD(−) group, AD group, and controls.Conclusions Parietal/precuneus hypometabolism may be associated with clinical characteristics in DLB patients. Further multiple imaging modalities that are sensitive to AD-type pathology are needed to reveal the neurobiological basis of the AD-like metabolic pattern. Copyright © 2014 John Wiley & Sons, Ltd.
    International Journal of Geriatric Psychiatry 03/2015; 30(3). DOI:10.1002/gps.4144 · 3.09 Impact Factor
  • Source
    • "In order to evaluate the decrease in the regional cerebral metabolic rate of glucose (CMRglc) in all patients, the CMRglc for each patient was compared using three-dimensional stereotactic surface projection (3D-SSP) analysis with an age-matched normative database consisting of data from 77 normal healthy volunteers between 41 and 84 years of age (36 men and 41 women) [19]. The difference in CMRglc between each patient and this database was expressed as a Z-score (normal mean-individual value/normal SD) and superimposed onto 3D-SSP maps [20] [21]. Hypometabolism in the PVC was measured based on the average extent of CMRglc reduction in each primary visual cortex on the [ 18 F]-FDG PET scans at a Z-score of N1.0. "
    [Show abstract] [Hide abstract]
    ABSTRACT: We previously reported non-demented patients with glucose hypometabolism in the primary visual cortex (PVC), which is the preferentially affected region in patients with dementia with Lewy bodies (DLB). It remains unknown, however, whether these patients represent a prodromal DLB state. Eleven non-demented patients who attended our memory clinic for more than three years (mean follow-up period: 44±5months) were examined. All the patients had glucose hypometabolism in the PVC on [(18)F]-fluoro-d-glucose (FDG) positron emission tomography (PET) scans at baseline. Four patients, including one with a clinical history of occipital bleeding, exhibited no core or suggestive features of DLB. Seven patients reported recurrent nocturnal dream-enactment behavior, which is consistent with probable rapid eye movement (REM) sleep behavior disorder (RBD). The condition of the patient with occipital bleeding was stable, which is consistent with an underlying non-neurodegenerative disorder. Of the remaining 10 patients, 5 had stable cognitive conditions (non-converters) and 5 exhibited progression to dementia (converters). The clinical diagnoses of 4 patients with probable RBD were changed to probable DLB. Despite no differences in psychological profiles at baseline between non-converters and converters, the initial pattern of cortical metabolism differed: converters had lower glucose hypometabolism in the parietal and the lateral occipital cortex compared to non-converters. The metabolic reduction in the PVC is present in patients with prodromal DLB. Moreover, the spatial profiles of reduced glucose metabolism at baseline could help to define the distinct prognostic subgroup that has a greater risk of conversion to DLB.
    Journal of the neurological sciences 07/2013; 334(1-2). DOI:10.1016/j.jns.2013.07.013 · 2.26 Impact Factor
  • Source
    • "To quantify function deficits, normalized brain activity of each patient was compared with that of 18 normal controls (12 men and 6 women, mean age 27.2 ± 6.0 years) using Z-score analysis: (normal mean-individual value)/normal s.d. To measure the volume of Z-score change of the cerebral hemisphere, we used the stereotactic extraction estimation method developed by Mizumura et al (2003), which is an analytical method using a stereotactic region of interest template from the Talairach daemon (Talairach (Lancaster et al, 2000). For 12 cases, we performed stereotactic extraction estimation analysis in the delayed images of IMZ in the acute and chronic stages. "
    [Show abstract] [Hide abstract]
    ABSTRACT: We evaluated cortical damages following traumatic brain injury (TBI) in the acute phase with [(123)I] iomazenil (IMZ) single photon emission computed tomography (SPECT). In all, 12 patients with cerebral contusion following TBI were recruited. All patients underwent IMZ SPECT within 1 week after TBI. To investigate the changes in distribution of IMZ in the cortex in the chronic phase, after conventional treatment, patients underwent IMZ SPECT again. A decrease in the accumulation of radioligand for the central benzodiazepine receptor in the cortex corresponding to the contusion revealed with computed tomography (CT) scans and magnetic resonance imaging (MRI) were shown on IMZ SPECT in the acute phase in all patients. In 9 of 12 patients (75%), images of IMZ SPECT obtained in the chronic phase of TBI showed that areas with a decreased distribution of IMZ were remarkably reduced in comparison with those obtained in the acute phase. Both CT scans and MRI showed a normal appearance of the cortex morphologically, where the binding potential of IMZ recovered in the chronic phase. Reduced binding potential of radioligand for the central benzodiazepine receptor is considered to be an irreversible reaction; however, in this study, IMZ accumulation in the cortex following TBI was recovered in the chronic phase in several patients. [(123)I] iomazenil SPECT may have a potential to disclose a reversible vulnerability of neurons following TBI.
    Journal of cerebral blood flow and metabolism: official journal of the International Society of Cerebral Blood Flow and Metabolism 10/2010; 30(10):1673-81. DOI:10.1038/jcbfm.2010.75 · 5.34 Impact Factor
Show more