The effect of pregnancy upon pulmonary function in normal women.

American Journal of Obstetrics and Gynecology (Impact Factor: 3.88). 12/1956; 72(5):963-9.
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    ABSTRACT: Pregnancy is a normal but altered physiologic state that results in significant hormonal, mechanical, and circulatory changes. The increases in progesterone and estrogen associated with pregnancy contribute to vascular and central nervous system effects, changes in the balance of bronchoconstrictor and bronchodilator prostanoids, and increases in peptide hormones that alter connective tissue characteristics. The course of pregnancy is accompanied by structural changes to the ribcage and abdominal compartments as a consequence of the hormonal changes and the enlarged uterus. Cardiac output, pulmonary blood flow, and circulating blood volume are all increased due to increased metabolic demands. This increase in blood volume without an increase in red cell mass results in a decreased hemoglobin concentration. Keywordslung mechanics, oxygenation, ventilation, respiratory physiology, pregnancy
    12/2008: pages 19-26;
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    ABSTRACT: Background & Objectives: The aim of the present study was to monitor the changes that occur in pulmonary function tests in the different trimesters of pregnancy as compared with that of control group i.e., non pregnant women. Materials & Methods: The study consists of recording the Pulmonary Function Tests of four groups of female subjects including pregnant women of various phases of gestational period i.e., 12 weeks, 24 weeks 36 weeks and control group of non pregnant women using computerized Medspiror. The different static lung function parameters measured in this study were vital Capacity (VC), FEV1 and Peak Expiratory Flow Rate (PEFR). PEFR was measured with Mini Wright’s peak flow meter. Results: We observed a statistically significant decrease in PEFR (p < 0.0001), a significant increase in VC & no significant change FEV1 in different trimesters of pregnancy. Conclusion: Comparative study of pulmonary function tests on different trimesters of pregnancy showed that different respiratory parameters like PEFR were compromised significantly due to mechanical pressure of gravid uterus, diaphragm restricting the movement of lungs. VC showed a significant increase in different trimester’s when compared with the non pregnant state whereas FEV1 showed no significant change. The respiratory system undergoes physiological and anatomical changes during pregnancy and we observed a significant decrease in PEFR and increase in VC among pregnant women.
    International Journal of Research in Health Sciences. 01/2014; 2(1):41-46.
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    ABSTRACT: Bei 62 Frauen (41 Schwangere, 10 Wchnerinnen, 11 Kontrollflle) wurden mit Hilfe der Ganzkrperplethysmographie statische und dynamische Ventilationsgren untersucht. Die Schwangeren wurden in 3 Gruppen eingeteilt: Gruppe A 8.–20. Schwangerschaftswoche, Gruppe B 20.–28. Schwangerschaftswoche, Gruppe C 28.–40. Schwangerschaftswoche. Die Untersuchungen hatten folgende Ergebnisse:Whrend der Schwangerschaft kommt es 1. zu einer signifikanten Erniedrigung der Totalkapazitt. Sie ist bedingt durch die Abnahme des exspiratorischen Reservevolumens und der funktionellen Residualkapazitt, 2. zu einer Abnahme des Atemgrenzwertes, wobei die relative Einsekundenkapazitt unverndert bleibt und 3. zu einer statistisch aufflligen (p=5%) Erhhung des Atemwegswiderstandes.Die maximalen Vernderungen liegen in der 26.–28. Schwangerschaftswoche (zusammenfassende Darstellung Abb. 12).Es besteht eine Korrelation zwischen der Abnahme der funktionellen Residualkapazitt und der Zunahme des Atemwegswiderstandes; die Vernderungen sind als schwangerschaftsspezifisch anzusehen, da bei der Gruppe Nicht-Schwangere keine Korrelation besteht. Da gleichzeitig whrend der Schwangerschaft die Lungendurchblutung und die alveolre Ventilation (Belftung) erhht sind, werden Einschrnkungen, die bei der Mehrzahl der statischen und dynamischen Ventilationsgren in der Schwangerschaft beobachtet werden z. T. kompensiert.The pulmonary ventilation of 62 women (41 pregnant-, 10 post partum-, 11 control cases) was studied by means of bodyplethysmography. The gestation group was subdivided into group A 8–20 weeks of pregnancy, group B 20–28 weeks and group C 28–40 weeks of gestation. The study has the following result: During pregnancy occurs 1. a significant lowering of total lung capacity due to decrease of the exspiratory reserve volume and the functional residual capacity, 2. a decrease of maximal breathing capacity (maximal voluntary ventilation) whereas the forced exspiratory volume in percent of vital capacity volume (FEV1.0) remained unchanged and 3. an increase of the resistance (p=5%). The maximum of these alterations was found in the 26–28 week of pregnancy. The correlation between the decrease of functional residual capacity and increase of resistance is gestation-specific; the group of the control cases does not show such a relation. The above described changes of pulmonary ventilation during gestation do not lead to disturbances of arterialization of the arterial blood since the lung perfusion during pregnancy and the alveolar ventilation are increased whereby the lowering of the pulmonary ventilation is compensated.
    Archives of Gynecology and Obstetrics 01/1971; 210(2):208-234. · 1.33 Impact Factor