Skills (19)
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108 Questions4467 Followers
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54 Questions5990 Followers
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27 Questions968 Followers
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56 Questions1237 Followers
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14 Questions142 Followers
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137 Questions7394 Followers
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275 Questions7966 Followers
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41 Questions1152 Followers
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85 Questions4575 Followers
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25 Questions512 Followers
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1 Question185 Followers
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28 Questions472 Followers
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Research experience
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Jan 2011–
presentResearch: Therapeutic vaccines candidates based on ErbB family proteins
Centro de Inmunología Molecular · Tumor Biology · Multivalent VaccinesCuba · La Habana -
Jan 2010–
Nov 2010Research: Therapeutic vaccines candidates based on Epidermal Growth Factor (EGF)
Centro de Inmunología Molecular · Tumor Biology · Multivalent VaccinesCuba · La Habana -
Oct 2009–
presentResearch: Large scale studies about the indiced-fit effect of proteins
Centro de Inmunología Molecular · Tumor Biology · NanobiologyCuba · La Habana -
Oct 2007–
Jun 2009Research: Development of a new algorithm for prediction of class II T-cell epitopes
Centro de Inmunología Molecular · Systems Biology · Molecular systems BiologyCuba · La Habana
Education
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Sep 2004–
Jun 2009University of Havana
Biochemistry · BScCuba · La Habana
Other
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LanguagesSpanish, English, French
Questions and Answers (5) View all
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Question asked in scientific literatureOpen Does anyone know about a supplier for full-text journal acces service (payed or not)?I need information about any supplier of full-text acces service of papers (Hinari-like), wich integrates biomed and biotech journals of NPG, Wiley, S... [more]I need information about any supplier of full-text acces service of papers (Hinari-like), wich integrates biomed and biotech journals of NPG, Wiley, ScienceDirect, Elsevier, Oxford Journals and similar publishers. Thanks in advanceBy Yasser Almeida · Center of Molecular ImmunologyFollowing
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Question asked in Bioinformatic Tools1 How to get ontologies from a PDB IDs list?I have a list of PDB IDs list and I need to get ontology data to verify any enrichment of protein family, function, cellular localization, etc. Which ... [more]I have a list of PDB IDs list and I need to get ontology data to verify any enrichment of protein family, function, cellular localization, etc. Which tool is the more suitable?By Yasser Almeida · Center of Molecular ImmunologyFollowing
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Answer added in Protein Overexpression25 How can I interpret this image?Yasser Almeida · Center of Molecular ImmunologyThe proposal of the endosomal localization it is not so clear for me, as the endosomes are formed mainly containing extracellular proteins or membrane... [more]The proposal of the endosomal localization it is not so clear for me, as the endosomes are formed mainly containing extracellular proteins or membrane proteins after a stimulus. Its more probable that your protein, as overexpresed, are located in vesicles from RE or Golgi. The ER has mechanisms to discard proteins misfolded (due for overexpresion) and this could one of them. Have you look for co-localization in this organelles? For ER you can use an anti-Calreticulin or anti-Calnexin antibodies, for example. For Golgi there are many markers you can use.Following
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Answer added in Cell Biology4 Lysosomal vs. Nuclear EGFR TraffickingBy Yasser Almeida · Center of Molecular ImmunologyYasser Almeida · Center of Molecular ImmunologyThanks for your answers...!! I've read your suggested papers and gave me some insights about the EGFR trafficking. My question is rather about which i... [more]Thanks for your answers...!! I've read your suggested papers and gave me some insights about the EGFR trafficking. My question is rather about which intracellular factor regulate the sorting of the endosome cargo to lysosomes or other organelles, since endosome is a crossroad in this trafficking. It's clear, from the paper of Roepstorff (2009), that the affinity of the ligand influence this phenomena. :)Following
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Question asked in Cell Biology4 Lysosomal vs. Nuclear EGFR TraffickingUpon Ligand binding (EGF, TGF-alpha) EGFR is internalized and finally sorted to degradation in lysosomes, or translocated to the nucleus, where it reg... [more]Upon Ligand binding (EGF, TGF-alpha) EGFR is internalized and finally sorted to degradation in lysosomes, or translocated to the nucleus, where it regulates the expression of several genes. Which factor determines or modulates the EGFR traficking to lysosomes or nucleus?By Yasser Almeida · Center of Molecular ImmunologyFollowing