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Publications
Publications (131)
Surface-enhanced Raman scattering (SERS) spectroscopy is an effective technique that can reveal molecular structure and molecular interaction details. Semiconductor-based SERS platforms exhibit multifaceted tunability and unique selectivity to target molecules as well as high spectral reproducibility. However, the detection sensitivity of semicondu...
Large-capacity energy storage devices are attracting widespread research attention. However, the decreased capacity of these devices due to cold weather is a huge obstacle for their practical use. In this study, an electrochemical self-adaptive reconstructed Cux S/Cu(OH)2 -based symmetric energy storage device is proposed. This device provides a sa...
The accurate, sensitive, and selective on-site screening of volatile aldehyde biomarkers for lung cancer is of utmost significance for preclinical cancer diagnosis and treatment. Applying surface-enhanced Raman scattering (SERS) for gas sensing remains difficult due to the small Raman cross section of most gaseous molecules and interference from ot...
Glutathione (GSH) plays a vital role in many physiological processes, and its abnormal levels have been found to be associated with several diseases. In contrast to traditional methods using electron donor-containing electrolytes for photoelectrochemical (PEC) sensing, in this study, a target-driven electron donor generation in a PEC electrode was...
Chiral chemicals have attracted significant interest in the pharmaceutical industry, yet the separation methods to get pure enantiomers from racemic mixture are still challenging. To date, the separation of enantiomers still mainly depends on chromatography using high-cost chiral stationary phases. Herein, wood channels were used as the handheld in...
Enzyme-mimicking nanoparticles play a key role in important catalytic processes, from biosensing to energy conversion. Therefore, understanding and tuning their performance is crucial for making further progress in biological applications. We developed an efficient and sensitive electrochemical method for the real-time monitoring of the glucose oxi...
Skin infections are major threats to human health, causing ∼500 incidences per 10 000 person-year. In patients with diabetes mellitus, particularly, skin infections are often accompanied by a slow healing process, amputation, and even death. Timely diagnosis of skin infection strains and on-site therapy are vital in human health and safety. Herein,...
As a biomarker of periodontitis, sensitive and timely monitoring of hydrogen sulfide (H2S) in exhaled breath at room temperature (RT) is important for the early intervention of oral diseases. However, the required high operation temperature to achieve high sensitivity is still a technical challenge for directly monitoring exhaled breath. In this st...
Metal-organic frameworks (MOFs) demonstrate strong potential in biosample separation. However, the obtained MOFs powders are unsuitable for recovery techniques in an aqueous solution, especially the challenges of withdrawing MOFs particles and expanding their functions for specific applications. Herein, a general strategy is designed utilizing meta...
Bacterial contamination in diets is a major threat to human health and a global health problem. The development of sensitive methods for rapid discrimination of benign and pathogenic bacteria is essential. Herein, using self-standing Au/TiO2 nanotubes as a surface-enhanced Raman spectroscopy (SERS) substrate, rapid and sensitive bacteria discrimina...
Enantioselective identification of chiral molecules is of paramount importance in medical science, biochemistry, and pharmaceutics owing to the configuration-dependent activities of enantiomers. However, the identical physicochemical properties of enantiomers remain challenging in chiral sensing. In this study, inspired by the peroxidase-mimicking...
Monosaccharides play significant roles in daily metabolism in living organisms. Although various devices have been constructed for monosaccharide identification, most rely on the specificity of the natural enzyme. Herein, inspired by natural ionic channels, an asymmetrical MOF-in-nanochannel architecture is developed to discriminate monosaccharide...
Atomically dispersed Pt single atoms (SAs) have been reported to be a highly effective co-catalyst on TiO2 for photocatalytic H2 generation. Many TiO2 supports have been explored for hosting Pt...
Solar-driven photo-electrocatalysis using semiconductor photoelectrodes offers a promising advance for sustainable and environmental-friendly energy utilization technology. At the same time, the inherent drawbacks of TiO2-based materials, such as limited light absorption and low carrier density, limit their practical applications. Engineering nanoa...
Accurate detection of trace biomarkers in biological samples is a key task in diagnostic testing, but it remains challenging due to the high concentration of other physiologically relevant interferences. This work presents a new electrochemiluminescence (ECL) sensing device based on a bio‐inspired nanochannel membrane (NM) guarded with two differen...
Hospital-acquired infections and antibiotic-resistant pathogens are major threats to human health. We develop an antibacterial film that maintains the long-term stability of titania (TiO2) while minimizing the disadvantages, the low photocatalytic efficiency of TiO2, especially in visible light, that limits the application of TiO2. Here, TiO2 nanot...
Charged components can be effectively separated and enriched based on ion concentration polarization (ICP) effect for sample clean up and enhancement of detection sensitivity in analytical chemistry. Concerning the role of electrolyte, current studies on electrokinetic stacking with ICP mainly focused on the ionic strength, and the knowledge about...
Rapid and sensitive detection of bacteria from a complex real media remains a challenge. Herein, we report a visual bacterial sensing assay with excellent specificity, anti-interference ability, and sensitivity based on a surface plasmon resonance (SPR)-enhanced peroxidase (POD) mimetic. The POD mimetic based on Pt nanoparticles (NPs) asymmetricall...
As a marker molecule in respiratory gases for the pulmonary disease asthma, nitric oxide (NO) has attracted much attention for real-time gas monitoring. However, low sensitivity, poor selectivity, and high operating temperature limit the practical applications of metal oxide semiconductor (MOS) based chemiresistor gas sensors. Herein, by deliberate...
Taking advantage of the intrinsic photocatalysis of TiO2, hydrophilic reactor arrays were lithographically patterned on a hydrophobic paper via a simple UV irradiation. As a proof-of-concept, alkaline phosphatase (ALP) was used as the model analyte for colorimetric analysis. As ALP can induce hydrolysis of pyrophosphate-Zn(II) framework, the releas...
With increasing attention to personalized healthcare, miniaturized and easily implementable devices are desired for point-of-care testing (POCT). Herein, hydrophilic patterns were designed on freestanding TiO2 nanotube arrays (TiNTs) as nanoreactors for a naked-eye colorimetric assay. With a high aspect ratio, TiNTs can provide a long observation l...
As an intriguing and intrinsic feature of life, chirality is highly associated with many significant biological processes. Simultaneous recognition and quantification of enantiomers remains a major challenge. Here, a sensitive enantiomer identification device is developed on TiO2 nanochannels via the design of cascade recognition-quantification zon...
It is important to detect cancer biomarkers at an early stage of tumor development for the effective diagnosis and treatment of cancer. As a well-known probe for detecting superoxide (·O2-) radicals, nitro blue tetrazolium (NBT) can rapidly react with ·O2- to form a hydrophobic formazan precipitate. In this study, by deliberately utilizing this rea...
The increasing organic and microbiological pollutions in fresh water caused by human activities and industrial development have become a global concern nowadays. In this study, three-dimensional (3D) hierarchical FeS2/TiO2 structures with nanotube geometries were grown on a Ti mesh (M-TNTAs-FeS2). Benefitting from the abundant available reactive si...
Chiral differentiation is an important topic in diverse fields ranging from pharmaceutics to chiral synthesis. The improvement of sensitivity and the elucidation of the mechanism of chiral recognition are still the two main challenges. Herein, a plasmon-free semiconductive surface-enhanced Raman spectroscopy (SERS) substrate with sensitive chiral r...
Enrichment and separation of specific endogenous molecules are essential for disease diagnosis and the pharmaceutical industry. Although many solid sorbents have been developed for target molecule enrichment, simultaneous separation of multitargets is still a challenge for adsorbents. In this study, we develop a multitarget selective sorbent based...
Although surface-enhanced Raman spectroscopy (SERS) has been applied for gathering fingerprint information, even in single molecule analysis, the decayed Raman signals in aqueous solutions largely obstruct the on-site insight reaction process. In this study, large-scaled semiconductor films with multi-walled (TiO2/WO3/TiO2) nanopore distribution ar...
With the wide application of supercapacitors, it has been recognized that the drop of energy storage capacity due to cold environmental temperatures limits their utilization efficiency. In this study, a binder-free Ni/Co-layered double hydroxide (LDH)-based high-performance energy storage device is constructed on Ni foam by in situ electrochemicall...
Transition metal-based materials are an excellent alternative high cost Pt and Pt-group metals as the anode material in direct methanol fuel cells (DMFCs). However, similar to Pt-based anode, these catalysts can also be poisoned by the by-product intermediates produced by methanol oxidation reaction (MOR). In this study, CoNi bi-component nanosheet...
The development of anode materials with high-rate capability is critical to high-power lithium batteries. T-Nb 2 O 5 has been widely reported to exhibit pseudocapacitive behavior and fast lithium storage capability. However, the...
Chiral enantiomers have different effects on biological processes. Enantiomer separation is significant and necessary. Herein, a photothermal (PT) effect-derived enantioselective desorption strategy based on homochiral Au/TiO2 nanotubes (NTs) is developed. Using 3,4-dihydroxyphenylalanine (DOPA) as the model enantiomer, an obvious selective desorpt...
A Janus cargo has been developed via the combination of magnetic mesoporous silica (MMS) with asymmetric decoration of Pt nanoparticles (PtNPs). Mesoporous morphology of MMS provides plenty of space for loading photosensitizers and targeting agents; the magnetic feature endows the as-formed nanospheres with satisfactory isolation function in remova...
Pathogenic bacteria can cause the outbreaks of disease and threaten human health, which stimulates the development of advanced detection techniques. Herein, a specific and sensitive electrochemical biosensor for Gram-negative bacteria was established based on the conductive polymer with artificial muscle properties. The effective recognition was ac...
Although TiO2 with outstanding photocatalytic activity has wide applications as a photo-to-electricity conversion material, the electrochemical energy storage of TiO2-based electrodes is commonly restricted by inherent limitations such as intrinsic low theoretical specific capacitance and poor electroconductivity. In this study, we introduce highly...
The high cost and easy denaturation of natural enzymes under environmental conditions largely hinder their practical usefulness in sensing devices. Currently, great efforts have been focused on exploring of novel functional nanomaterials to replace natural enzymatic systems. In this study, we developed a hydrothermal growth of free-standing cobalt...
A cost-effective, facile, and sensitive fluorescence sensing strategy for Pb2+ ion detection has been developed based on the fluorescence resonance energy transfer (FRET) between carbon quantum dots (CQDs) and Au nanoparticles (NPs). Glutathione (GSH)-synthesized CQDs acted as both the fluorescence donor and the sorbent to extract Pb2+ ions from th...
Effective isolation and removal of target tumor cells from patients' peripheral blood are of great importance to clinical prognosis and recovery. However, the extremely low quantity of target cells in peripheral blood becomes one of the challenges in this respect. Herein, we design and synthesize an innovative nanostructure based on magnetic TiO2 n...
Infectious diseases caused by bacteria are a global threat to the human health. Here, we propose a solvent “irrigation” technique to endow TiO2 nanotubes (NTs) to precisely modify with functional nanomaterials, and apply them in constructing a near-infrared (NIR) light controlled drug-delivery system for rapid necrosis of bacteria. In this design,...
Nanomaterial-based artificial enzyme mimetics have attracted increasing attention because of their robust stability, adjustable activity, and cost-effectiveness. In this study, we developed a simple and effective method to synthesize highly dispersed ultrafine PdCo alloys with peroxidase- and catalase-like activities. The aberration-corrected trans...
Determination of circulating tumor cells (CTCs) is crucial for cancer diagnosis and therapy at an early stage. However, extremely low concentration of CTCs in peripheral blood makes the detection of CTCs challenging. In this study, a reusable cytosensor was developed for rapid detection of CTCs based on excellent photoelectrochemical (PEC) characte...
A photocatalysis-enzyme coupled system represents a most promising approach towards artificial photosynthesis and a direct use of solar energy for the synthesis of specific organic molecules or fuel. In contrast...
Artificial solid-state nanopores and porous nanochannels based electrochemical sensing technique has demonstrated great advantages such as high sensitivity and minimalized equipment. However, their application is largely hindered by the complex...
Boosting photocatalytic performance via external fields is an alternative and effective solution for improving the application performance of existing photocatalysts. Herein, using α-Fe2O3-decorated TiO2 nanotube arrays as a model, we demonstrate the influence of magnetic field (MF)-direction on the photogenerated charge-carrier transfer behavior a...
Electrochemiluminescence resonance energy transfer (ECL-RET) is a powerful analytical strategy based on the resonance energy transfer (RET) between an efficient electrochemiluminescence (ECL) emitter and an especially matched energy acceptor. However, finding a suitable energy acceptor with good stability and efficiency energy absorption capability...
Steam generation via harvesting solar energy is one of the promising approaches for seawater desalination. Nowadays, organic contamination in seawater represents a great challenge that needs to be solved. Specially, low-molecular-weight organic molecules may easily pass through distillation membranes with water steam and enter freshwater sources. I...
Capture, analysis, and inactivation of circulating tumor cells (CTCs) have emerged as the important issues for the early diagnosis and therapy of cancer. In this study, an all-in-one sensing device was developed by integrating magnetic metal-organic framework (magMOF) nanoparticles (NPs) and TiO2 nanotube arrays (TiNTs). The magMOF NPs are composed...
A smooth TiO 2 nanotube-based membrane (S-TiNM) is demonstrated to be effective in reducing the Raman-scattering loss in 3D porous structures. Using the photocatalytic reduction of 4-nitrothiophenol as a model, the...
Nanozymes have been used in colorimetric and electrochemical sensing because of their low cost and high stability. However, the wide applications of nanozymes in sensing devices are largely limited due to their poor selectivity. In this study, unlike traditional methods using prepared nanozymes for target detection, we designed a target-driven nano...
Maintaining the high activity of an enzyme is a fundamental requirement to widen the application of metal-organic frameworks (MOFs) in the biotechnology, biosensor, and biomedicine fields. However, it is still challenging to monitor and understand an MOF environment-related activity for an enzyme. Here, we developed a MOFs-in-nanochannels configura...
Titanium dioxide (TiO2) nanomaterials have attracted much interest in life science and biological fields because of their excellent photocatalytic activity and good biocompatibility. However, owing to wide band-gap, photocatalysis of TiO2 can be only triggered by UV light. The limited transparent depth of UV light and the generated reactive oxygen...
Electroporation induced by “point discharge” effect is an effective technique for bacteria inactivation. Rapidly monitoring the elec-troporation induced inactivation process is important for screening nanomaterials with high antimicrobial performance. In this study, we develop a facile strategy to in situ monitor the electroporation induced antimic...
The low penetration depth of UV light in mammalian tissue is the critical limitation for the use of TiO2 based photocatalysis in biomedical applications. In this work, we develop an effective near infrared (NIR) active photocatalytic platform that consists of a shell structure of upconversion nanocrystals decorated on a core of Au/dark-TiO2. The he...
Au nanoparticles were asymmetrically fabricated at one tip of TiO 2 nanochannels by combining the photocatalytic reaction and limited penetration of light. Using the asymmetrical nanochannel-based membrane as a plasma absorber,...
Biomarkers in blood or tissue provide essential information for clinical screening and early disease diagnosis. However, increasing the sensitivity of detecting biomarkers remains a major challenge in a wide variety of electrochemical immunoassays. Herein, we present an electrochemiluminescence (ECL) immunosensing strategy with 1: Nn amplification...
Rational design of active sites for electrocatalyst is crucial to achieving high efficiency of electrochemical reactions. Contrary to the shape-controlled method, herein, we report a selective segregation-etch strategy to highly increase the active sites of the bimetallic alloy as a high-performance electrocatalyst. The surface composition of PdCo...
The level of hydrogen sulfide in the brain and vasculature has long been associated with human health and diseases. Hence, simple and robust analytical tools allowing determination of hydrogen sulfide levels are highly desirable. In this work, a biomineralization-driven ion gate in TiO2 nanochannel arrays for H2S sensing was designed and developed....
A portable dual-mode sensing platform based on self-standing TiO 2 nanotube membrane is developed for simultaneous performing of both the qualitative analysis by naked eye and quantitative analysis by ionic current....
A mild anion exchange approach is proposed for the synthesis of alloyed Co–Fe bimetallic disulfide. Abundant structural disorders and tunable compositions are effectively induced by the anion exchange process. The alloyed Co–Fe bimetallic disulfide exhibits a low overpotential of 205 mV to reach a current density of 100 mA cm⁻² in an acidic electro...
As a highly oxygen-dependent process, the effect of photodynamic therapy (PDT) is often obstructed by the premature leakage of photosensitizers and the lack of oxygen in hypoxic cancer cells. To overcome these limitations, this study designs serum albumin protein (BSA) encapsulated Pt nanoclusters (PtBSA) as O2-supplied biocoats, and further cooper...
As a highly electrochemically active transition-metal oxide (TMO), cobalt monoxide (CoO) has been extensively investigated for applications in lithium-ion battery and electrochemical oxygen evolution. However, its capacitive performance has been rarely studied due to the intrinsic low conductivity and poor stability. Here, we report an asymmetric s...
Exfoliation of graphitic carbon nitride (g-C3N4) into ultrathin nanosheets is usually the first step for its perspective applications. In contrast to the traditional time-consuming ultrasonication approach, a rapid and high-yield method to synthesis g-C3N4 nanosheets is desirable. In this study, we develop an efficiency and versatile strategy to ex...
Hierarchical CoS 2 microspheres were prepared and modified with a cationic ionic liquid (IL). The composite shows enhanced oxygen evolution reaction (OER) performances attributed to the fact that OER equilibrium is...
Bacteria sensing and inactivating is one of the key steps to prevent bacteria propagation and transfer. Here, using Ag nanoparticles-grafted tungsten oxide film (WO3/Ag), we developed a multifunctional platform that may act as a SERS substrate for sensitively capturing and counting bacteria. Moreover, we demonstrated that the use of photon-triggere...
Electrochromic materials are widely used in smart windows. An ideal future electrochromic window would be able to control visible light transmission, tune building's heat conversion of near-infrared (NIR) solar radiation, and reduce attacks by microorganisms. To date, most of the reports have primarily focused on visible-light transmission modulati...
Designing new earth-abundant and low-cost catalysts toward the hydrogen evolution reaction (HER) plays a key role in realization of hydrogen economy. In this study, we demonstrate that excellent HER activity is achieved with core-shell Co3O4@CoS2 nanoneedle arrays synthesized by an instantaneous thermal treatment of nanoneedle precursor in H2S atmo...
Affordable methodologies for detecting tumor markers at low concentrations are very important for early diagnosis. The two key requirements for designing ultrasensitive photoelectrochemical (PEC) immunosensors are highly active PEC platforms and amplified recognition events on the transducer surfaces. Herein we report the development of an effectiv...
We report a facile and economical method to form a carbon layer embedded into self-organized titanium dioxide nanotubes (C/TiO2 NTs) with a double-walled morphology using a one-step pyrolysis method. The carbon precursors are the organic electrolyte remaining in the nanotube channels during the anodic growth of the TiO2 nanotubes (TiO2 NTs). By com...
In this work, we use a double-layered stack of TiO2 nanotubes (TiNTs) to construct a visible-light-triggered drug delivery system. The key for visible light drug release is a hydrophobic cap on the nanotubes containing Au nanoparticles (AuNPs). The AuNPs allow for a photocatalytic scission of the hydrophobic chain under visible light. To demonstrat...
In this work, we use a double-layered stack of TiO2 nanotubes (TiNTs) to construct a visible-light-triggered drug delivery system. The key for visible light drug release is a hydrophobic cap on the nanotubes containing Au nanoparticles (AuNPs). The AuNPs allow for a photocatalytic scission of the hydrophobic chain under visible light. To demonstrat...
Abstract Nitrogen-doped carbon materials have attracted tremendous attention because of their high activity in electrocatalysis. In the present work, cocoon silk - a biomass material is used to prepare porous carbon fibers due to its abundant nitrogen content. The as-prepared carbon microfibers have been activated and disintegrated into carbon nano...
In this work we introduce a facile procedure that allows a highly conformal coating of self-organized TiO2 nanotubes (NTs) with a graphite-like thin carbon layer. This provides a platform to enhance the functionality of TiO2 nanotubes for a wide range of applications. Here we show that such modified nanotubes can serve as a 3D scaffold for an ideal...
In this work we introduce a facile procedure that allows a highly conformal coating of self-organized TiO2 nanotubes (NTs) with a graphite-like thin carbon layer. This provides a platform to enhance the functionality of TiO2 nanotubes for a wide range of applications. Here we show that such modified nanotubes can serve as a 3D scaffold for an ideal...
Amperometric biosensors consisting of oxidase and peroxidase have attracted great attention because of their wide application. The current work demonstrates a novel approach to construct an enzymatic biosensor based on TiO2 nanotube arrays (TiNTs) as a supporting electrode on which Prussian Blue (PB)-an "artificial enzyme peroxidase" and enzyme glu...
Silver orthophosphate (Ag3PO4) is a low band-gap photocatalyst that has received considerable research interest in recent years. In this work, the magnetically Ag3PO4/TiO2/Fe3O4 heterostructured nanocomposite is synthesized. The nanocomposite exhibits remarkably enhanced photocatalytic activity, cycling stability and long-term durability in the pho...
